A possible association between the val158met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects

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A possible association between the val158met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects
Authors: Ryota Hashimoto, Hiroko Noguchi, Hiroaki Hori, Kazutaka Ohi, Yuka Yasuda, Masatoshi Takeda, Hiroshi Kunugi
Citation: Neuroscience letters 428 (1): 17-20. 2007 November
Database(s): PubMed (PMID/17945417)
DOI: 10.1016/j.neulet.2007.09.036.
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A possible association between the val158met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects reports a personality genetics study with the COMT gene polymorphism val158met and personality traits measured with the Temperament and Character Inventory. Also cognitive function is measured with the WAIS-R and Wisconsin Card Sorting Test (WCST).

[edit] Subjects

Subject group #1 (help)
Healthy Japanese
Subjects/♂/♀: 139 /  /
Age: (–)
Nationality: Japanese
Approval: Institutional ethical committee
Databases:

Group 1 of 139 healthy Japanese were included in the study.

The study on the human subjects was approved by the Institutional ethical committee. Subjects with medical problems, head trauma, neurosurgery or substance abuse were excluded.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
COMT met158val val/val TCI Novelty seeking 21.5 3.9 77 Healthy Japanese 17945417
COMT met158val met/val TCI Novelty seeking 22.1 5.0 45 Healthy Japanese 17945417
COMT met158val met/met TCI Novelty seeking 20.5 4.3 17 Healthy Japanese 17945417
COMT met158val val/val TCI Harm avoidance 17.2 6.2 77 Healthy Japanese 17945417
COMT met158val met/val TCI Harm avoidance 19.6 5.7 45 Healthy Japanese 17945417
COMT met158val met/met TCI Harm avoidance 20.8 4.0 17 Healthy Japanese 17945417
COMT met158val val/val TCI Reward dependence 15.1 3.9 77 Healthy Japanese 17945417
COMT met158val met/val TCI Reward dependence 15.7 3.8 45 Healthy Japanese 17945417
COMT met158val met/met TCI Reward dependence 14.8 2.9 17 Healthy Japanese 17945417
COMT met158val val/val TCI Persistence 4.4 2.0 77 Healthy Japanese 17945417
COMT met158val met/val TCI Persistence 4.7 1.7 45 Healthy Japanese 17945417
COMT met158val met/met TCI Persistence 4.6 2.0 17 Healthy Japanese 17945417
COMT met158val val/val TCI Self-directedness 30.1 6.4 77 Healthy Japanese 17945417
COMT met158val met/val TCI Self-directedness 28.7 5.5 45 Healthy Japanese 17945417
COMT met158val met/met TCI Self-directedness 29.8 5.0 17 Healthy Japanese 17945417
COMT met158val val/val TCI Cooperativeness 29.0 4.4 77 Healthy Japanese 17945417
COMT met158val met/val TCI Cooperativeness 28.3 5.6 45 Healthy Japanese 17945417
COMT met158val met/met TCI Cooperativeness 29.8 4.1 17 Healthy Japanese 17945417
COMT met158val val/val TCI Self-transcendence 10.3 4.7 77 Healthy Japanese 17945417
COMT met158val met/val TCI Self-transcendence 11.2 4.6 45 Healthy Japanese 17945417
COMT met158val met/met TCI Self-transcendence 9.8 4.6 17 Healthy Japanese 17945417
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