A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity

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Paper (help)
A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
Authors: Stephen B. Manuck, Janine D. Flory, Robert E. Ferrell, J. John Mann, Matthew F. Muldoon
Citation: Psychiatry Research 95 (1): 9-3. 2000 July
Database(s): PubMed (PMID/10904119)
DOI: 10.1016/S0165-1781(00)00162-1.
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A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity reports a personality genetics study on the MAOA gene genetic polymorphisms MAOA-uVNTR and CA repeat in intron 2 with personality traits assessed with Aggression Impulsivity Index, Life History of Aggression (LHA), Barratt Impulsiveness Scale (BIS) and Buss-Durkee Hostility Inventory (BDHI).

For the MAOA-uVNTR polymorphism the paper distinguishes between four different genetic polymorphisms:

  1. 3
  2. 3.5
  3. 4
  4. 5

1 and 4 (3 and 5, i.e., Sabol 1998 low transcriptional activity) are grouped together against 2 and 3 (3.5 and 4 , Sabol 1998 high transcriptional activity).

For the MAOA CA repeat their were two groups[1]

  1. Short with 1-3 repeats
  2. Long with 4-8 repeats.

[edit] Subjects

Subject group #1 (help)
Non-hispanic white male Americans
Subjects/♂/♀: 110 / 110 / 0
Age: 45.2 (27–60)
Nationality: American
Approval: define approval
Databases:

Group 1 of 110 non-hispanic white male Americans with 110 males and 0 females were included in the study. The American group had a mean age of 45.2 with a range from 27 to 60.

The subjects participated in the University of Pittsburgh Cholesterol and Risk Evaluation (CARE) project.

[edit] Results

[edit] References

  1. Vanyukov (1995). "A dinucleotide repeat polymorphism at the gene for monoamine oxidase A and measures og aggressiveness". Psychiatry Research 59: 35-41.
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