Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects

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Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects
Authors: A. Veronica Witte, Agnes Flöel, Patrycja Stein, Markus Savli, Leonhard-Key Mien, Wolfgang Wadsak, Christoph Spindelegger, Ulrike Moser, Martin Fink, Andreas Hahn, Markus Mitterhauser, Kurt Kletter, Siegfried Kasper, Rupert Lanzenberger
Citation: Human Brain Mapping 30 (8): 2558-2570. 2009
Database(s): PubMed (PMID/19086022)
DOI: 10.1002/hbm.20687.
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Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects reports a positron emission tomography study with the carbon-11 WAY-100635 radioligand for the examination of serotonin-1A receptor distribution in the human brain and its correlation with the aggression personality trait of subjects.

[edit] Results

Results are reported as Spearman correlation coefficient between 13 brain regions and aggression and 2 aggression subscores, spontaneous aggression and impulsiveness.

The P-values for aggression are Bonferroni corrected across the 13 brain regions: 0.05/13=0.0038.

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