Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits

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Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits
Authors: Alexander Strobel, L. Gutknecht, C. Rothe, A. Reif, R. Mossner, Y. Zeng, B. Brocke, Klaus-Peter Lesch
Citation: Journal of Neural Transmission 110 (12): 1445-1443. 2003 December
Database(s): PubMed (PMID/14666415)
DOI: 10.1007/s00702-003-0072-0.
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Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits reports a personality genetics study on the C-1019G polymorphism in the HTR1A gene and personality traits measured with NEO PI-R as well as the Tridimensional Personality Questionnaire.

Contents

[edit] Subjects

Subject group #1 (help)
Healthy German university students and staff
Subjects/♂/♀: 284 / 71 / 213
Age: 22.2 ±5.0 (18–59)
Nationality: German
Approval: define approval
Databases:

Group 1 of 284 healthy German university students and staff with 71 males and 213 females were included in the study. The German group had a mean age of 22.2 with a range from 18 to 59.


The subjects were recruited from two other studies: No association between dopamine D4 receptor gene exon III and -512C/T polymorphism and novelty seeking and Further evidence for a modulation of novelty seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
HTR1A C-1019G C/C NEO PI-R Neuroticism 89.24 23.18 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Neuroticism 97.23 25.58 225 Healthy German university students and staff 14666415
HTR1A C-1019G C/C NEO PI-R Anxiety 15.56 6.13 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Anxiety 17.73 6.59 225 Healthy German university students and staff 14666415
HTR1A C-1019G C/C NEO PI-R Angry hostility 13.22 4.73 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Angry hostility 14.23 4.94 225 Healthy German university students and staff 14666415
HTR1A C-1019G C/C NEO PI-R Depression 13.46 5.20 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Depression 15.88 6.27 225 Healthy German university students and staff 14666415
HTR1A C-1019G C/C NEO PI-R Self-consciousness 17.15 5.27 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Self-consciousness 17.92 5.01 225 Healthy German university students and staff 14666415
HTR1A C-1019G C/C NEO PI-R Impulsiveness 17.80 4.80 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Impulsiveness 18.06 4.44 225 Healthy German university students and staff 14666415
HTR1A C-1019G C/C NEO PI-R Vulnerability 12.05 4.68 59 Healthy German university students and staff 14666415
HTR1A C-1019G G NEO PI-R Vulnerability 13.40 5.44 225 Healthy German university students and staff 14666415

[edit] Related studies

  1. 5-HT1A polymorphism and self-transcendence in mood disorders
  2. Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology
  3. The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings

[edit] Critique

  1. Only NEO PI-R Neuroticism scores are reported, not other NEO PI-R traits nor TPQ traits.
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