An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans

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Paper (help)
An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans
Authors: Se Joo Kim, Young Shin Kim, Shin Young Kim, Hong Shick Lee, Chan-Hyung Kim
Citation: Neuroscience Letters 401 (1-2): 154-158. 2006 June
Database(s): PubMed (PMID/16584839)
DOI: 10.1016/j.neulet.2006.03.006.
Link(s): http://yalerei.org/chldstdy/faculty/pdf/KIM-SJ(COMT).pdf
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An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans reports a personality genetics study between personality traits measured with the Temperament and Character Inventory and the val158met polymorphims in the COMT gene and the MAOA-uVNTR polymorphism.

A related study is An association study of the 5-HTTLPR and COMT genes polymorphisms and personality traits.

[edit] Subjects

Subject group #1 (help)
Male Korean hospital staff
Subjects/♂/♀: 138 / 138 / 0
Age: (21–35)
Nationality: Korean
Approval: Youngdong Severance Hospital and Hallym Sacred Heart Hospital
Databases:

Group 1 of 138 male Korean hospital staff with 138 males and 0 females were included in the study. The Korean group was from 21 up to 35 years old.

The study on the human subjects was approved by the Youngdong Severance Hospital and Hallym Sacred Heart Hospital.
Subject group #2 (help)
Female Korean hospital staff
Subjects/♂/♀: 148 / 0 / 148
Age: (21–35)
Nationality: Korean
Approval: Youngdong Severance Hospital and Hallym Sacred Heart Hospital
Databases:

Group 2 of 148 female Korean hospital staff with 0 males and 148 females were included in the study. The Korean group was from 21 up to 35 years old. The study on the human subjects was approved by the Youngdong Severance Hospital and Hallym Sacred Heart Hospital.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
COMT met158val val/val TCI Harm avoidance 17.0 5.8 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Harm avoidance 16.2 8.5 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Harm avoidance 14.3 7.6 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Novelty seeking 19.1 6.3 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Novelty seeking 17.0 5.5 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Novelty seeking 19.7 5.2 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Reward dependence 14.9 4.3 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Reward dependence 14.6 4.3 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Reward dependence 15.9 4.9 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Persistence 3.8 1.8 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Persistence 4.5 1.9 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Persistence 5.1 1.6 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Self-directedness 25.6 8.1 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Self-directedness 26.8 6.3 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Self-directedness 28.8 7.2 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Cooperativeness 29.2 6.6 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Cooperativeness 30.6 5.6 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Cooperativeness 32.6 4.9 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Self-transcendence 10.6 5.8 74 Male Korean hospital staff 16584839
COMT met158val met/val TCI Self-transcendence 12.3 6.5 48 Male Korean hospital staff 16584839
COMT met158val met/met TCI Self-transcendence 11.6 5.3 16 Male Korean hospital staff 16584839
COMT met158val val/val TCI Harm avoidance 19.6 16.3 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Harm avoidance 16.3 7.0 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Harm avoidance 13.8 5.7 12 Female Korean hospital staff 16584839
COMT met158val val/val TCI Novelty seeking 17.3 5.4 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Novelty seeking 18.0 5.5 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Novelty seeking 18.3 5.0 12 Female Korean hospital staff 16584839
COMT met158val val/val TCI Reward dependence 17.0 3.1 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Reward dependence 16.3 5.5 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Reward dependence 16.6 2.9 12 Female Korean hospital staff 16584839
COMT met158val val/val TCI Persistence 3.5 1.6 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Persistence 4.0 2.0 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Persistence 4.6 1.3 12 Female Korean hospital staff 16584839
COMT met158val val/val TCI Self-directedness 25.6 7.8 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Self-directedness 27.2 8.2 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Self-directedness 30.1 5.3 12 Female Korean hospital staff 16584839
COMT met158val val/val TCI Cooperativeness 32.1 4.7 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Cooperativeness 31.8 5.5 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Cooperativeness 32.3 3.4 12 Female Korean hospital staff 16584839
COMT met158val val/val TCI Self-transcendence 9.0 4.3 76 Female Korean hospital staff 16584839
COMT met158val met/val TCI Self-transcendence 9.7 5.2 60 Female Korean hospital staff 16584839
COMT met158val met/met TCI Self-transcendence 8.4 3.6 12 Female Korean hospital staff 16584839
MAOA uVNTR 3 TCI Harm avoidance 16.2 7.0 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Harm avoidance 16.5 7.1 73 Male Korean hospital staff 16584839
MAOA uVNTR 3 TCI Novelty seeking 19.0 5.8 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Novelty seeking 18.0 6.2 73 Male Korean hospital staff 16584839
MAOA uVNTR 3 TCI Reward dependence 14.7 4.5 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Reward dependence 15.1 4.1 73 Male Korean hospital staff 16584839
MAOA uVNTR 3 TCI Persistence 4.1 1.7 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Persistence 4.3 1.9 73 Male Korean hospital staff 16584839
MAOA uVNTR 3 TCI Self-directedness 26.2 6.9 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Self-directedness 26.6 7.8 73 Male Korean hospital staff 16584839
MAOA uVNTR 3 TCI Cooperativeness 30.2 5.3 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Cooperativeness 29.9 6.9 73 Male Korean hospital staff 16584839
MAOA uVNTR 3 TCI Self-transcendence 11.0 5.3 65 Male Korean hospital staff 16584839
MAOA uVNTR 4 TCI Self-transcendence 11.5 6.6 73 Male Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Harm avoidance 16.8 7.5 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Harm avoidance 19.1 7.2 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Harm avoidance 16.9 7.5 32 Female Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Novelty seeking 18.6 5.5 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Novelty seeking 16.7 5.2 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Novelty seeking 18.4 5.6 32 Female Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Reward dependence 16.6 3.0 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Reward dependence 16.5 3.0 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Reward dependence 17.0 3.5 32 Female Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Persistence 3.9 2.5 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Persistence 3.7 1.8 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Persistence 3.9 1.6 32 Female Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Self-directedness 28.5 7.0 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Self-directedness 25.4 8.2 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Self-directedness 26.6 8.8 32 Female Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Cooperativeness 33.3 3.8 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Cooperativeness 31.3 5.7 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Cooperativeness 31.5 5.0 32 Female Korean hospital staff 16584839
MAOA uVNTR 3/3 TCI Self-transcendence 9.6 5.0 44 Female Korean hospital staff 16584839
MAOA uVNTR 3/4 TCI Self-transcendence 8.9 4.6 66 Female Korean hospital staff 16584839
MAOA uVNTR 4/4 TCI Self-transcendence 10.0 4.1 32 Female Korean hospital staff 16584839

[edit] Related studies

  1. Henderson (missing year). missing title. missing journal missing volume: missing pages.
  2. S. J. Tsai (2003). "Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females". Neuroscience Letters missing volume: missing pages.
  3. Reuter (2005). "Association of the functional catechol-O-methyltransferase val158met polymorphism with the personality trait of extraversion". missing journal missing volume: missing pages.
  4. Benjamin (2000). "An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimentional personality questionnaire persistence scores in normal subjects". missing journal missing volume: missing pages.
  5. Smolka (2005). "Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex". missing journal missing volume: missing pages.
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