Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms

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Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms
Authors: Stefan Viktor Vormfelde, Imke Hoell, Mladen Tzvetkov, Katja Jamrozinski, Daniel Sehrt, Jurgen Brockmoller, Eric Leibing
Citation: Journal of Psychiatric Research 40 (6): 568-566. 2006 September
Database(s): PubMed (PMID/16313923)
DOI: 10.1016/j.jpsychires.2005.10.002.
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Extract:

Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms reports a personality genetics study on the serotonin transporter gene (SLC6A4) 5-HTTLPR and STin2 genetic polymorphisms with personality traits assessed with NEO PI-R and Tridimensional Personality Questionnaire.

There is a very important erratum, that states that the short and long variant of the 5-HTTLPR were interchanged.[1]


[edit] Subjects

Subject group #1 (help)
Healthy German Caucasian university students
Subjects/♂/♀: 195 / 97 / 98
Age: (–)
Nationality: German
Approval: Ethics committee of the University of Göttingen
Databases:

Group 1 of 195 healthy German Caucasian university students with 97 males and 98 females were included in the study.

The study on the human subjects was approved by the Ethics committee of the University of Göttingen.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 92 22 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 98 21 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 92 26 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Extraversion 122 18 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Extraversion 120 20 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Extraversion 113 17 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Openness to experience 130 15 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Openness to experience 131 15 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Openness to experience 125 17 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Agreeableness 118 16 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/long NEO PI-R Agreeableness 118 15 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Agreeableness 113 17 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Conscientiousness 120 19 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Conscientiousness 114 21 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Conscientiousness 119 17 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long TPQ Novelty seeking 16.0 5.5 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short TPQ Novelty seeking 16.7 5.1 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short TPQ Novelty seeking 14.6 5.4 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long TPQ Harm avoidance 14.5 5.8 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short TPQ Harm avoidance 14.9 5.9 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short TPQ Harm avoidance 15.1 5.5 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long TPQ Reward dependence 20.1 4.3 38 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/short TPQ Reward dependence 19.8 4.3 40 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR short/short TPQ Reward dependence 19.0 4.4 20 Healthy German Caucasian female university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 91 21 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 80 23 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 81 26 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Extraversion 117 22 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Extraversion 112 19 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Extraversion 121 22 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Openness to experience 124 20 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Openness to experience 119 17 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Openness to experience 118 19 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Agreeableness 112 17 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Agreeableness 108 17 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Agreeableness 111 16 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long NEO PI-R Conscientiousness 114 21 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short NEO PI-R Conscientiousness 117 21 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short NEO PI-R Conscientiousness 112 19 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long TPQ Novelty seeking 18.3 5.6 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short TPQ Novelty seeking 15.6 5.7 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short TPQ Novelty seeking 17.0 5.2 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long TPQ Harm avoidance 13.6 6.2 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short TPQ Harm avoidance 12.0 7.0 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short TPQ Harm avoidance 11.1 7.5 16 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/long TPQ Reward dependence 18.1 4.5 31 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR long/short TPQ Reward dependence 16.9 4.5 50 Healthy German Caucasian male university students 16313923
SLC6A4 5-HTTLPR short/short TPQ Reward dependence 18.1 4.6 16 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Neuroticism 95 21 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Neuroticism 95 25 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Neuroticism 92 26 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 NEO PI-R Neuroticism 92 18 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Neuroticism 104 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Extraversion 114 19 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Extraversion 120 17 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Extraversion 125 18 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 NEO PI-R Extraversion 125 18 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Extraversion 150 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Openness to experience 127 15 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Openness to experience 131 14 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Openness to experience 128 16 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 NEO PI-R Openness to experience 133 27 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Openness to experience 161 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Agreeableness 117 12 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Agreeableness 114 18 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Agreeableness 122 16 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 NEO PI-R Agreeableness 121 20 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Agreeableness 135 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Conscientiousness 116 21 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Conscientiousness 117 20 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Conscientiousness 118 20 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 NEO PI-R Conscientiousness 119 20 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Conscientiousness 143 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 TPQ Novelty seeking 15.6 5.2 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 TPQ Novelty seeking 16.3 5.2 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 TPQ Novelty seeking 16.2 6.4 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 TPQ Novelty seeking 16.3 5.5 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 TPQ Novelty seeking 14.0 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 TPQ Harm avoidance 15.4 5.5 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 TPQ Harm avoidance 14.2 5.8 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 TPQ Harm avoidance 15.5 6.5 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 TPQ Harm avoidance 12.3 2.9 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 TPQ Harm avoidance 19.8 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 TPQ Reward dependence 19.8 4.0 34 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/10 TPQ Reward dependence 19.2 4.2 43 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/10 TPQ Reward dependence 20.6 4.5 15 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/9 TPQ Reward dependence 20.6 6.4 5 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 10/9 TPQ Reward dependence 26.8 0 1 Healthy German Caucasian female university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Neuroticism 82 22 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Neuroticism 85 25 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Neuroticism 85 23 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Neuroticism 117 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Extraversion 111 22 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Extraversion 118 20 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Extraversion 119 17 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Extraversion 137 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Openness to experience 116 18 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Openness to experience 121 17 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Openness to experience 132 17 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Openness to experience 105 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Agreeableness 109 15 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Agreeableness 106 17 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Agreeableness 121 14 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Agreeableness 94 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 NEO PI-R Conscientiousness 119 16 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 NEO PI-R Conscientiousness 112 23 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 NEO PI-R Conscientiousness 111 25 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 NEO PI-R Conscientiousness 146 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 TPQ Novelty seeking 14.7 5.2 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 TPQ Novelty seeking 19.0 5.6 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 TPQ Novelty seeking 17.3 5.3 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 TPQ Novelty seeking 12.7 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 TPQ Harm avoidance 12.9 7.2 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 TPQ Harm avoidance 11.3 7.0 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 TPQ Harm avoidance 12.9 5.7 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 TPQ Harm avoidance 18.4 0 1 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/12 TPQ Reward dependence 16.7 4.6 44 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 12/10 TPQ Reward dependence 17.6 4.6 35 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/10 TPQ Reward dependence 18.8 3.8 17 Healthy German Caucasian male university students 16313923
SLC6A4 STin2 10/9 TPQ Reward dependence 24.5 0 1 Healthy German Caucasian male university students 16313923

[edit] References

  1. Stefan Viktor Vormfelde, Imke Hoell, Mladen Tzvetkov, Katja Jamrozinski, Daniel Sehrt, Jürgen Brockmöller, Eric Leibing (2008). "Corrigendum to "Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms" (J Psychiatr Res 40 (2006) 568-576)". Journal of Psychiatric Research 42: 424. doi: 10.1016/j.jpsychires.2007.03.004.
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