Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females

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Paper (help)
Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females
Authors: Eiji Shimizu, Kenji Hashimoto, Shintaro Ohgake, Hiroki Koizumi, Naoe Okamura, Kaori Koike, Mihisa Fujisaki, Masaomi Iyo
Citation: Progress in neuro-psychopharmacology & biological psychiatry 30 (1): 99-93. 2006 January
Database(s): PubMed (PMID/16236416)
DOI: 10.1016/j.pnpbp.2005.08.021.
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Extract:

Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females reports a personality genetics study on the angiotensin I-converting enzyme gene (ACE) and personality traits assessed with the NEO PI-R and Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Healthy Japanese medical staff and students
Subjects/♂/♀: 164 /  /
Age: (–)
Nationality: Japanese
Approval: Ethics committee of the Chiba University of School of Medicine
Databases:

Group 1 of 164 healthy Japanese medical staff and students were included in the study.

The study on the human subjects was approved by the Ethics committee of the Chiba University of School of Medicine.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
ACE 291-bp repeat ins/ins TCI Novelty seeking 21.4 5.20 33 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Harm avoidance 19.1 5.50 33 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Reward dependence 14.2 3.70 33 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Persistence 3.91 2.10 33 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat del TCI Novelty seeking 21.2 5.66 41 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat del TCI Harm avoidance 19.4 7.38 41 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat del TCI Reward dependence 15.7 4.14 41 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat del TCI Persistence 4.54 1.78 41 Healthy Japanese male medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Novelty seeking 19.9 5.23 48 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Harm avoidance 20.3 5.63 48 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Reward dependence 16.9 3.38 48 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat ins/ins TCI Persistence 4.67 2.10 48 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat del TCI Novelty seeking 22.4 5.38 62 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat del TCI Harm avoidance 18.2 6.26 62 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat del TCI Reward dependence 16.6 3.28 62 Healthy Japanese female medical staff and students 16236416
ACE 291-bp repeat del TCI Persistence 4.16 2.02 62 Healthy Japanese female medical staff and students 16236416

[edit] Critique

  1. Biased reporting: NEO PI-R personality scores were not reported (as not significant), while the significant TCI scores were
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