Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese

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Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese
Authors: Norio Yasui-Furukori, Ayako Kaneda, Kumiko Iwashima, Manabu Saito, Taku Nakagami, Shoko Tsuchimine, Sunao Kaneko
Citation: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 144B (6): 724-727. 2007 September
Database(s): PubMed (PMID/17357148)
DOI: 10.1002/ajmg.b.30430.
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Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese reports a personality genetics study on the CYP2C19 gene and personality traits assessed with the Temperament and Character Inventory.

The study finds the strongest association to be to harm avoidance, and within that trait to anticipatory worry and shyness with strangers. These traits are not the same as the strongest associations in the study CYP2C19 polymorphism affects personality traits of Japanese females.

[edit] Subjects

Subject group #1 (help)
Japanese medical students and staff
Subjects/♂/♀: 352 / 186 / 166
Age: 29.9 ±11.3 (18–69)
Nationality: Japanese
Approval: Ethics Committee of Hirosaki University School of Medicine
Databases:

Group 1 of 352 japanese medical students and staff with 186 males and 166 females were included in the study. The Japanese group had a mean age of 29.9 with a range from 18 to 69. The study on the human subjects was approved by the Ethics Committee of Hirosaki University School of Medicine.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
CYP2C19 CYP2C19 1/1 TCI Novelty seeking 21.3 4.0 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Novelty seeking 21.6 5.2 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Novelty seeking 21.1 4.5 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Harm avoidance 18.7 5.8 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Harm avoidance 20.5 6.1 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Harm avoidance 21.1 6.7 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Reward dependence 15.2 2.9 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Reward dependence 14.7 3.5 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Reward dependence 14.6 3.2 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Persistence 4.5 1.7 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Persistence 4.2 1.9 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Persistence 4.4 2.0 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Self-directedness 27.3 6.7 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Self-directedness 26.0 6.5 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Self-directedness 26.0 6.8 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Cooperativeness 28.4 5.3 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Cooperativeness 27.8 5.1 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Cooperativeness 28.5 5.5 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Self-transcendence 11.3 5.6 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Self-transcendence 10.0 4.5 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Self-transcendence 10.5 4.8 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Anticipatory worry 5.2 2.3 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Anticipatory worry 5.8 2.4 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Anticipatory worry 6.3 2.8 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Fear of uncertainty 5.3 1.5 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Fear of uncertainty 5.5 1.7 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Fear of uncertainty 5.4 1.6 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Shyness with strangers 4.3 1.9 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Shyness with strangers 5.0 1.7 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Shyness with strangers 5.1 2.0 58 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 1/1 TCI Fatigability and asthenia 3.8 2.2 113 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/1 TCI Fatigability and asthenia 4.1 2.1 181 Japanese medical students and staff 17357148
CYP2C19 CYP2C19 -1/-1 TCI Fatigability and asthenia 4.4 2.4 58 Japanese medical students and staff 17357148
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