Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals

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Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals
Authors: Shoko Tsuchimine, Norio Yasui-Furukori, Ayako Kaneda, Manabu Saito, Taku Nakagami, Kimihiko Sato, Sunao Kaneko
Citation: Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 (8): 1932-1935. 2008 December
Database(s): Google Scholar cites PubMed (PMID/18845200)
DOI: 10.1016/j.pnpbp.2008.09.012.
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Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals reports a personality genetics study on the MAOA-uVNTR polymorphism and personality traits measured with Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Female Japanese medical students and staff
Subjects/♂/♀: 245 / 0 / 245
Age: (18–69)
Nationality: Japanese
Approval: Ethics Committee of Hirosaki University School of Medicine
Databases:

Group 1 of 245 female Japanese medical students and staff with 0 males and 245 females were included in the study. The Japanese group was from 18 up to 69 years old.

The study on the human subjects was approved by the Ethics Committee of Hirosaki University School of Medicine.
Subject group #2 (help)
Male Japanese medical students and staff
Subjects/♂/♀: 304 / 304 / 0
Age: (18–69)
Nationality: Japanese
Approval: Ethics Committee of Hirosaki University School of Medicine
Databases:

Group 2 of 304 male Japanese medical students and staff with 304 males and 0 females were included in the study. The Japanese group was from 18 up to 69 years old. The study on the human subjects was approved by the Ethics Committee of Hirosaki University School of Medicine.

616 subjects was enrolled, but only 558 completed the TCI. 9 Subjects had the rare 2 or 5 repeat and were excluded from the association analysis leaving 549 subjects.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
MAOA uVNTR 3/3 TCI Novelty seeking 22.4 5.3 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/3 TCI Harm avoidance 20.3 5.5 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/3 TCI Reward dependence 14.9 3.3 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/3 TCI Persistence 3.9 1.8 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/3 TCI Self-directedness 26.9 6.4 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/3 TCI Cooperativeness 27.4 4.9 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/3 TCI Self-transcendence 9.9 4.3 80 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Novelty seeking 21.0 4.6 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Harm avoidance 20.1 5.7 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Reward dependence 15.4 3.0 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Persistence 4.3 2.0 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Self-directedness 27.0 6.5 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Cooperativeness 28.5 5.0 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 3/4 TCI Self-transcendence 10.5 4.8 125 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Novelty seeking 21.2 4.2 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Harm avoidance 18.6 6.1 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Reward dependence 15.9 3.6 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Persistence 4.9 1.7 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Self-directedness 27.7 5.4 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Cooperativeness 28.7 5.8 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 4/4 TCI Self-transcendence 10.5 4.2 40 Female Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Novelty seeking 21.8 5.2 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Harm avoidance 18.8 6.8 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Reward dependence 14.4 3.4 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Persistence 4.6 1.9 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Self-directedness 27.6 6.7 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Cooperativeness 27.5 5.7 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 3 TCI Self-transcendence 10.1 5.3 118 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Novelty seeking 21.9 5.2 116 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Harm avoidance 19.6 6.3 116 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Reward dependence 15.0 3.1 116 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Persistence 4.4 1.7 116 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Self-directedness 26.2 7.3 116 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Cooperativeness 28.3 4.9 116 Male Japanese medical students and staff 18845200
MAOA uVNTR 4 TCI Self-transcendence 10.8 5.9 116 Male Japanese medical students and staff 18845200

[edit] Critique

  1. The study is reasonably sized.
  2. The persistence in females is reported to have a P-value of P=0.012 in the abstract, but other places in the manuscript reports it as P=0.016, the former being a post hoc test.
  3. The results on persistence with a P-value is given prominence in the abstract and the conclusion. Given the multiple tests (14 tests) a P-value on P=0.016 is usually not that interesting. No correction for multiple comparisons are made.
  4. The authors conclude that there is a gender-specific contribution of the MAOA-VNTR. However, this conclusion cannot be made based on the statistical results presented in article, since no direct test (an interaction effect) is made on that hypothesis.
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