Association between the estrogen receptor TA polymorphism and harm avoidance

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Paper (help)
Association between the estrogen receptor TA polymorphism and harm avoidance
Authors: R. Gade-Andavolu, J. Macmurray, D. E. Comings, R. Calati, A. Chiesa, A. Serretti
Citation: Neuroscience Letters 467 (2): 155-158. 2009 December
Database(s): PubMed (PMID/19822194)
DOI: 10.1016/j.neulet.2009.10.028.
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Extract:

Association between the estrogen receptor TA polymorphism and harm avoidance reports a personality genetics study on the ESR1 gene with harm avoidance personality traits assessed with the Temperament and Character Inventory Revised.

Previous personality genetics studies, Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects? and Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women, also examined ESR1.

[edit] Subjects

Subject group #1 (help)
Caucasian American university students
Subjects/♂/♀: 190 / 106 / 84
Age: (21–49)
Nationality: American
Approval: Institutional Review Board at the Jerry L. Pettis Memorial Veterans Administration Medical Center
Databases:

Group 1 of 190 caucasian American university students with 106 males and 84 females were included in the study. The American group was from 21 up to 49 years old. The study on the human subjects was approved by the Institutional Review Board at the Jerry L. Pettis Memorial Veterans Administration Medical Center.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
ESR1 TA repeat short/short TCI-R Anticipatory worry 52.17 11.8 46 Caucasian American male university students 19822194
ESR1 TA repeat short/short TCI-R Fear of uncertainty 49.07 9.6 46 Caucasian American male university students 19822194
ESR1 TA repeat short/short TCI-R Shyness with strangers 50.30 10.9 46 Caucasian American male university students 19822194
ESR1 TA repeat short/short TCI-R Fatigability and asthenia 51.09 11.4 46 Caucasian American male university students 19822194
ESR1 TA repeat short/short TCI-R Harm avoidance 50.94 11.0 46 Caucasian American male university students 19822194
ESR1 TA repeat long/short TCI-R Anticipatory worry 47.27 9.1 44 Caucasian American male university students 19822194
ESR1 TA repeat long/short TCI-R Fear of uncertainty 46.09 9.7 44 Caucasian American male university students 19822194
ESR1 TA repeat long/short TCI-R Shyness with strangers 46.81 10.3 44 Caucasian American male university students 19822194
ESR1 TA repeat long/short TCI-R Fatigability and asthenia 47.21 8.3 44 Caucasian American male university students 19822194
ESR1 TA repeat long/short TCI-R Harm avoidance 45.91 9.2 44 Caucasian American male university students 19822194
ESR1 TA repeat long/long TCI-R Anticipatory worry 43.43 6.6 16 Caucasian American male university students 19822194
ESR1 TA repeat long/long TCI-R Fear of uncertainty 40.75 8.3 16 Caucasian American male university students 19822194
ESR1 TA repeat long/long TCI-R Shyness with strangers 45.16 8.6 16 Caucasian American male university students 19822194
ESR1 TA repeat long/long TCI-R Fatigability and asthenia 44.89 5.7 16 Caucasian American male university students 19822194
ESR1 TA repeat long/long TCI-R Harm avoidance 41.99 7.6 16 Caucasian American male university students 19822194
ESR1 TA repeat short/short TCI-R Anticipatory worry 51.45 9.9 31 Caucasian American female university students 19822194
ESR1 TA repeat short/short TCI-R Fear of uncertainty 51.03 8.9 31 Caucasian American female university students 19822194
ESR1 TA repeat short/short TCI-R Shyness with strangers 52.07 9.5 31 Caucasian American female university students 19822194
ESR1 TA repeat short/short TCI-R Fatigability and asthenia 55.94 13.1 31 Caucasian American female university students 19822194
ESR1 TA repeat short/short TCI-R Harm avoidance 53.43 9.8 31 Caucasian American female university students 19822194
ESR1 TA repeat long/short TCI-R Anticipatory worry 50.66 10.5 39 Caucasian American female university students 19822194
ESR1 TA repeat long/short TCI-R Fear of uncertainty 50.97 8.9 39 Caucasian American female university students 19822194
ESR1 TA repeat long/short TCI-R Shyness with strangers 51.04 9.8 39 Caucasian American female university students 19822194
ESR1 TA repeat long/short TCI-R Fatigability and asthenia 50.87 10.8 39 Caucasian American female university students 19822194
ESR1 TA repeat long/short TCI-R Harm avoidance 51.15 9.6 39 Caucasian American female university students 19822194
ESR1 TA repeat long/long TCI-R Anticipatory worry 47.68 8.7 14 Caucasian American female university students 19822194
ESR1 TA repeat long/long TCI-R Fear of uncertainty 49.14 6.4 14 Caucasian American female university students 19822194
ESR1 TA repeat long/long TCI-R Shyness with strangers 43.73 7.0 14 Caucasian American female university students 19822194
ESR1 TA repeat long/long TCI-R Fatigability and asthenia 46.75 7.2 14 Caucasian American female university students 19822194
ESR1 TA repeat long/long TCI-R Harm avoidance 45.76 6.5 14 Caucasian American female university students 19822194
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