Association of a functional BDNF polymorphism and anxiety-related personality traits

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Association of a functional BDNF polymorphism and anxiety-related personality traits
Authors: Undine E. Lang, Rainer Hellweg, Peter Kalus, Malek Bajbouj, Kirsten P. Lenzen, Thomas Sander, Dieter Kunz, Jurgen Gallinat
Citation: Psychopharmacology 180 (1): 95-99. 2005 June
Database(s): PubMed (PMID/15918078)
DOI: 10.1007/s00213-004-2137-7.
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Extract:

Association of a functional BDNF polymorphism and anxiety-related personality traits reports a personality genetics study on the rs6265 (val66met) genetic polymorphism in the BDNF gene with personality traits assessed with the NEO-FFI and State-Trait Anxiety Inventory.

[edit] Subjects

Subject group #1 (help)
Healthy German Caucasians
Subjects/♂/♀: 242 / 171 / 172
Age: 39.0 ±14.6 (–)
Nationality: German
Approval: Ethics committee of the Charité Medicine Berlin
Databases:

Group 1 of 242 healthy German Caucasians with 171 males and 172 females were included in the study. The German group had a mean age of 39.0. The study on the human subjects was approved by the Ethics committee of the Charité Medicine Berlin.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
BDNF met66val val/val STAI Anxiety state 34.28 7.6 218 Healthy German Caucasians 15918078
BDNF met66val val/met STAI Anxiety state 33.52 6.4 112 Healthy German Caucasians 15918078
BDNF met66val met/met STAI Anxiety state 33.46 6.2 13 Healthy German Caucasians 15918078
BDNF met66val val/val STAI Anxiety trait 35.01 7.4 218 Healthy German Caucasians 15918078
BDNF met66val met/val STAI Anxiety trait 33.39 6.5 112 Healthy German Caucasians 15918078
BDNF met66val met/met STAI Anxiety trait 32.03 4.6 13 Healthy German Caucasians 15918078
BDNF met66val val/val NEO-FFI Neuroticism 29.54 7.0 218 Healthy German Caucasians 15918078
BDNF met66val met/val NEO-FFI Neuroticism 28.4 6.5 112 Healthy German Caucasians 15918078
BDNF met66val met/met NEO-FFI Neuroticism 26.84 5.8 13 Healthy German Caucasians 15918078
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