Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
Authors: Klaus-Peter Lesch, D. Bengel, A. Heils, Sue Z. Sabol, Benjamin D. Greenberg, S. Petri, Jonathan Benjamin, C. R. Muller, Dean H. Hamer, Dennis L. Murphy
Citation: Science 274 (5292): 1527-1521. 1996 November
Database(s): Google Scholar cites PubMed (PMID/8929413)
DOI: 10.1126/science.274.5292.1527.
Link(s): http://www.homepage.psy.utexas.edu/HomePage/Group/AnimPersInst/Animal%20Personality%20PDFs/L/Lesch%20et%20al,%201996.pdf
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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region reports a personality genetics study with the 5-HTTLPR genetic polymorphism and personality traits assessed with NEO PI-R.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 53.4 12.0 72 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Extraversion 52.5 10.5 72 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Openness to experience 57.2 12.9 72 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Agreeableness 45.4 11.3 72 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Conscientiousness 43.5 11.6 72 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 57.8 13.2 106 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Extraversion 53.2 12.2 106 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Openness to experience 56.1 12.3 106 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Agreeableness 42.6 11.8 106 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Conscientiousness 40.5 13.5 106 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 56.6 11.2 43 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Extraversion 52.3 10.4 43 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Openness to experience 55.9 14.1 43 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Agreeableness 40.9 11.7 43 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Conscientiousness 42.1 12.4 43 American NIH and college sibling pairs 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 52.8 11.1 91 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Extraversion 55.6 10.5 91 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Openness to experience 61.0 10.1 91 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Agreeableness 50.5 9.7 91 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/long NEO PI-R Conscientiousness 47.8 10.0 91 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 55.5 11.0 141 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Extraversion 53.5 10.4 141 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Openness to experience 59.8 10.1 141 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Agreeableness 48.8 10.2 141 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR long/short NEO PI-R Conscientiousness 48.6 10.6 141 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 56.1 11.3 52 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Extraversion 52.1 11.1 52 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Openness to experience 59.3 8.9 52 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Agreeableness 49.8 11.2 52 American predominantely male homosexuals 8929413
SLC6A4 5-HTTLPR short/short NEO PI-R Conscientiousness 45.4 10.8 52 American predominantely male homosexuals 8929413
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