Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data

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Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
Authors: Marcus R. Munafò, Binnaz Yalcin, Saffron A. G. Willis-Owen, Jonathan Flint
Citation: Biological Psychiatry 63 (2): 197-196. 2008 January
Database(s): PubMed (PMID/17574217)
DOI: 10.1016/j.biopsych.2007.04.006.
Link(s): http://marcus-munafo.psy.bris.ac.uk/Publications/2008%20Biol%20Psychiatry%20a.pdf
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Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data reports an original personality genetics study and a meta-analysis on DRD4 exon 3 VNTR and C-521T genetic polymorphisms and personality traits such as novelty seeking.

The study extends a previous meta-analysis on the same polymorphisms DRD4 and novelty seeking: results of meta-analyses.

The report finds that DRD4 exon 3 VNTR seems not to be associated with novelty seeking, while C-521T perhaps is.

[edit] Included studies in the meta-analyses

[edit] DRD4 Exon 3

33 papers and further 8 extreme value design papers.

  1. Benjamin, 1996, Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking
  2. Ebstein, 1996, Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
  3. Malhotra, 1996, The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking
  4. Ebstein, 1997, Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking
  5. Gelernter, 1997, D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
  6. Jonsson, 1998, Lack of association between dopamine D4 receptor gene and personality traits
  7. Ono, Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects
  8. ...

[edit] C-521T

The meta-analysis extends a previous meta-analysis, DRD4 and novelty seeking: results of meta-analyses with new studies.

  1. Okuyama (2001). "Identification of a polymorphism in the promoter region of the DRD4 associated with the human novelty seeking personality trait". missing journal missing volume: missing pages.
  2. Ronai (2001). "Association between novelty seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene". missing journal missing volume: missing pages.
  3. Mitsuyasu (2001). "Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits". missing journal missing volume: missing pages.
  4. E. B. Bookman (2002). "DRD4 promoter SNPs and gender effects on extraversion in African Americans". Mol. Psychiatry missing volume: missing pages.
  5. Erik G. Jönsson (2002). "No association between dopamine D4 receptor gene variants and novelty seeking". Molecular Psychiatry missing volume: missing pages.
  6. A. Strobel (2002). "No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking". Mol. Psychiatry 7: 537-538.
  7. Lee (2003). "Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population". missing journal missing volume: missing pages. Data in this study was not available for Munafo et al.
  8. Strobel (2003). "Lack of association between polymorphisms of the dopamine D4 receptor gene and personality". Neuropsychobiology 47: 52-56.
  9. A. Strobel (2003). "Further evidence for a modulation of novelty seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants". Mol. Psychiatry 8: 371-372. This data was reported in the Strobel 2002 paper
  10. P. Eichhammer (2005). "Variation at the DRD4 promoter modulates extraversion in Caucasians". Mol. Psychiatry 10: missing pages.
  11. Vera E. Golimbet (2005). "Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population". Russian Journal of Genetics 41: 789-793. doi: 10.1007/s11177-005-0161-2.
  12. Vera E. Golimbet (2006). "Dopamine system genes and personality traits of extraversion and novelty seeking". Zh Vyssh Nerv Deiat Im I P Pavlova 56: 457-463.

Apart from these studies two extreme value studies are also listed:

  1. Ekelund (2001). missing title. missing journal missing volume: missing pages.
  2. Munafo el al. own study.
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