Association study of catechol-O-methyltransferase val158met polymorphism with personality traits in Japanese healthy volunteers

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Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers
Authors: Genki Ishii, Akihito Suzuki, Shingo Oshino, Hiroaki Shiraishi, Yoshihiko Matsumoto, Koichi Otani, Kaoru Goto
Citation: European psychiatry : the journal of the Association of European Psychiatrists 22 (7): 462-465. 2007 October
Database(s): PubMed (PMID/17761405)
DOI: 10.1016/j.eurpsy.2007.05.005.
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Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers reports a personality genetics study on the COMT polymorphism val158met and personality traits measured with the Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Male Japanese medical staff and students
Subjects/♂/♀: 246 / 256 / 0
Age: (18–60)
Nationality: Japanese
Approval: Ethics Committee of Yamagata University School of Medicine
Databases:

Group 1 of 246 male Japanese medical staff and students with 256 males and 0 females were included in the study. The Japanese group was from 18 up to 60 years old.

The study on the human subjects was approved by the Ethics Committee of Yamagata University School of Medicine.
Subject group #2 (help)
Female Japanese medical staff and students
Subjects/♂/♀: 232 / 0 / 232
Age: (18–60)
Nationality: Japanese
Approval: Ethics Committee of Yamagata University School of Medicine
Databases:

Group 2 of 232 female Japanese medical staff and students with 0 males and 232 females were included in the study. The Japanese group was from 18 up to 60 years old. The study on the human subjects was approved by the Ethics Committee of Yamagata University School of Medicine.

Subjects with past or present psychiatric disorders were excluded.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
COMT met158val val/val TCI Novelty seeking 21.8 4.8 122 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Harm avoidance 18.6 6.0 122 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Reward dependence 15.7 3.5 122 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Persistence 4.3 1.8 122 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Self-directedness 28.8 6.5 122 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Cooperativeness 27.0 5.5 122 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Self-transcendence 9.1 5.0 122 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Novelty seeking 22.1 5.1 101 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Harm avoidance 17.8 6.6 101 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Reward dependence 15.6 3.7 101 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Persistence 4.4 1.7 101 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Self-directedness 30.0 5.7 101 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Cooperativeness 28.8 5.8 101 Male Japanese medical staff and students 17761405
COMT met158val met/val TCI Self-transcendence 8.9 4.4 101 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Novelty seeking 24.3 4.1 23 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Harm avoidance 16.7 5.9 23 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Reward dependence 16.4 3.8 23 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Persistence 4.3 1.6 23 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Self-directedness 30.7 5.9 23 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Cooperativeness 29.7 4.1 23 Male Japanese medical staff and students 17761405
COMT met158val met/met TCI Self-transcendence 8.0 4.5 23 Male Japanese medical staff and students 17761405
COMT met158val val/val TCI Novelty seeking 21.5 5.1 129 Female Japanese medical staff and students 17761405
COMT met158val val/val TCI Harm avoidance 19.5 5.6 129 Female Japanese medical staff and students 17761405
COMT met158val val/val TCI Reward dependence 17.1 3.1 129 Female Japanese medical staff and students 17761405
COMT met158val val/val TCI Persistence 4.3 1.7 129 Female Japanese medical staff and students 17761405
COMT met158val val/val TCI Self-directedness 27.7 6.3 129 Female Japanese medical staff and students 17761405
COMT met158val val/val TCI Cooperativeness 28.9 4.0 129 Female Japanese medical staff and students 17761405
COMT met158val val/val TCI Self-transcendence 9.3 4.7 129 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Novelty seeking 21.6 5.6 88 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Harm avoidance 19.5 6.5 88 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Reward dependence 17.0 3.2 88 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Persistence 4.1 1.7 88 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Self-directedness 27.6 6.8 88 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Cooperativeness 29.0 4.9 88 Female Japanese medical staff and students 17761405
COMT met158val met/val TCI Self-transcendence 10.0 4.9 88 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Novelty seeking 19.7 4.5 15 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Harm avoidance 23.5 5.3 15 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Reward dependence 15.9 3.8 15 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Persistence 3.8 1.5 15 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Self-directedness 24.4 7.0 15 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Cooperativeness 28.9 5.8 15 Female Japanese medical staff and students 17761405
COMT met158val met/met TCI Self-transcendence 10.3 4.3 15 Female Japanese medical staff and students 17761405
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