Association study of the cytochrome P450 17 gene polymorphism with personality traits in healthy subjects

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Association study of the cytochrome P450 17 gene polymorphism with personality traits in healthy subjects
Authors: Yoshihiko Matsumoto, Akihito Suzuki, Naoshi Shibuya, Shingo Oshino, Mitsuhiro Kamata, Kaoru Goto, Koichi Otani
Citation: Behavioural Brain Research 194 (1): 21-24. 2008 December
Database(s): PubMed (PMID/18619494)
DOI: 10.1016/j.bbr.2008.06.017.
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Association study of the cytochrome P450 17 gene polymorphism with personality traits in healthy subjects reports a personality genetics study with the rs743572 (C-34T) genetic polymorphism in the CYP17A1 gene and personality traits assessed with the Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Japanese medical students and staff
Subjects/♂/♀: 595 /  /
Age: 28.5 ±9.1 (–)
Nationality: Japanese
Approval: Ethics Committee of Yamagata University School of Medicine
Databases:

Group 1 of 595 japanese medical students and staff were included in the study. The Japanese group had a mean age of 28.5. The study on the human subjects was approved by the Ethics Committee of Yamagata University School of Medicine.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
CYP17A1 C-34T T/T TCI Novelty seeking 20.6 4.6 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Harm avoidance 18.6 5.7 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Reward dependence 15.2 3.9 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Persistence 4.2 1.6 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Self-directedness 29.9 5.7 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Cooperativeness 27.1 5.9 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Self-transcendence 7.5 4.3 77 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Novelty seeking 22.2 5.0 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Harm avoidance 17.9 6.3 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Reward dependence 15.9 3.6 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Persistence 4.4 1.8 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Self-directedness 29.6 6.2 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Cooperativeness 28.5 5.2 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Self-transcendence 9.2 4.6 231 Male Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Novelty seeking 21.7 5.4 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Harm avoidance 19.4 6.2 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Reward dependence 17.2 3.3 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Persistence 3.9 1.7 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Self-directedness 28.0 6.2 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Cooperativeness 29.4 4.8 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T T/T TCI Self-transcendence 10.3 4.8 81 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Novelty seeking 21.1 5.1 206 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Harm avoidance 20.1 5.8 206 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Reward dependence 16.7 3.2 206 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Persistence 4.3 1.7 206 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Self-directedness 27.8 6.6 206 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Cooperativeness 28.6 4.5 206 Female Japanese medical students and staff 18619494
CYP17A1 C-34T C TCI Self-transcendence 9.4 4.7 206 Female Japanese medical students and staff 18619494
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