Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender

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Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender
Authors: Beverly H. Brummett, Ilene C. Siegler, Douglas R. McQuoid, Ingrid K. Svenson, Douglas A. Marchuk, David C. Steffens
Citation: Psychiatric genetics 13 (1): 13-18. 2003 March
Database(s): PubMed (PMID/12605095)
DOI: 10.1097/01.ypg.0000051093.88669.85.
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Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender reports a personality genetics study with NEO PI-R and 5-HTTLPR in elderly depressed and nondepressed Americans.

[edit] Subjects

Subject group #1 (help)
Elderly depressed and nondepressed Americans
Subjects/♂/♀: 202 / 73 / 129
Age: (–)
Nationality: American
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Group 1 of 202 elderly depressed and nondepressed Americans with 73 males and 129 females were included in the study.


Of the total 202 subjects 103 were depressed patients and 99 were controls.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 46.5 12.1 33 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 47.7 10.6 91 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 51.0 12.6 78 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR short/short NEO PI-R Agreeableness 53.9 9.2 33 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/short NEO PI-R Agreeableness 55.8 8.4 91 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/long NEO PI-R Agreeableness 53.9 9.8 78 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR short/short NEO PI-R Extraversion 50.0 10.7 33 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/short NEO PI-R Extraversion 47.0 9.9 91 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/long NEO PI-R Extraversion 46.9 8.8 78 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR short/short NEO PI-R Openness to experience 49.0 10.3 33 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/short NEO PI-R Openness to experience 47.7 11.7 91 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/long NEO PI-R Openness to experience 49.8 10.2 78 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR short/short NEO PI-R Conscientiousness 48.0 11.0 33 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/short NEO PI-R Conscientiousness 48.3 11.4 91 Elderly depressed and nondepressed Americans 12605095
SLC6A4 5-HTTLPR long/long NEO PI-R Conscientiousness 47.2 11.8 78 Elderly depressed and nondepressed Americans 12605095
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