BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
|BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism|
|Authors:||Antonio Terracciano, Toshiko Tanaka, Angelina R. Sutin, Barbara Deiana, Lenuta Balaci, Serena Sanna, Nazario Olla, Andrea Maschio, Manuela Uda, Luigi Ferrucci, David Schlessinger, Paul T. Costa, Jr.|
|Citation:||Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 35 (5): 1083-1089. 2010 April|
|Web:||Bing Google Yahoo! — Google PDF|
|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism reports a personality genetics study and meta-analysis on the BDNF gene val66met genetic polymorphism. In the original personality genetics study personality traits are assesed with NEO PI-R.
As a meta-analysis it extends an earlier meta-analysis Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) val66met polymorphism in anxiety disorders and anxiety-related personality traits.
|Subject group #1 (help)|
|Sardinians from the Lanusei Valley|
|Subjects/♂/♀:||1560 / /|
|Age:||42.7 ±17 (14–94)|
|Approval:||Institutional review boards in Italy and the USA|
Group 1 of 1560 sardinians from the Lanusei Valley were included in the study. The Italian group had a mean age of 42.7 with a range from 14 to 94. The study on the human subjects was approved by the Institutional review boards in Italy and the USA.The Sardinians (SardiNIA 2) were not overlapping with a previous study on Sardinians reported in Genome-wide association scan for five major dimensions of personality
|Subject group #2 (help)|
|Subjects/♂/♀:||1131 / /|
|Age:||57.3 ±15.5 (20–93)|
|Approval:||Local institutional review board|
Group 2 of 1131 community-dwelling Americans were included in the study. The American group had a mean age of 57.3 with a range from 20 to 93. The study on the human subjects was approved by the Local institutional review board.
The community-dwelling Americans were part of the Baltimore Longitudinal Study of Aging (BLSA). See also Variants of the serotonin transporter gene and NEO-PI-R neuroticism: no association in the BLSA and SardiNIA samples.
 Included studies in the meta-analysis
- Sen (2003). "A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression". missing journal missing volume: missing pages.
- Itoh (2004). "Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects". missing journal missing volume: missing pages.
- Undine E. Lang (2005). "Association of a functional BDNF polymorphism and anxiety-related personality traits". missing journal missing volume: missing pages.
- Saffron A. G. Willis-Owen (2005). "The val66met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism". missing journal missing volume: missing pages.
- M. Tochigi (2006). "No evidence for an association between the BDNF val66met polymorphism and schizophrenia or personality traits". Schizophr. Res. 87: 45-47.
- Hünnerkopf (2007). "Interaction between BDNF val66met and dopamine transporter gene variation influences anxiety-related traits". missing journal missing volume: missing pages.
- N. R. Wray (2008). "Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression". Psychiatr. Genet. 18: 219-225.
- Gatt (2009). "Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety". missing journal missing volume: missing pages.
- The authors previous samples.
 Not included
- Association study of a brain-derived neurotrophic factor (BDNF) val66met polymorphism and personality trait and intelligence in healthy young females
|BDNF||met66val||val/val||NEO PI-R||Neuroticism||46.8||8.3||770||Community-dwelling Americans||20042999|
|BDNF||met66val||met/val||NEO PI-R||Neuroticism||48.3||8.6||324||Community-dwelling Americans||20042999|
|BDNF||met66val||met/met||NEO PI-R||Neuroticism||44.2||10.2||37||Community-dwelling Americans||20042999|
|BDNF||met66val||val/val||NEO PI-R||Extraversion||51.5||9.9||770||Community-dwelling Americans||20042999|
|BDNF||met66val||met/val||NEO PI-R||Extraversion||49.1||9.6||324||Community-dwelling Americans||20042999|
|BDNF||met66val||met/met||NEO PI-R||Extraversion||50.0||10.2||37||Community-dwelling Americans||20042999|
Results for the community-dwelling Americans are also reported for subset consisting of only European-Americans.