BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism

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BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
Authors: Antonio Terracciano, Toshiko Tanaka, Angelina R. Sutin, Barbara Deiana, Lenuta Balaci, Serena Sanna, Nazario Olla, Andrea Maschio, Manuela Uda, Luigi Ferrucci, David Schlessinger, Paul T. Costa, Jr.
Citation: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 35 (5): 1083-1089. 2010 April
Database(s): PubMed (PMID/20042999)
DOI: 10.1038/npp.2009.213.
PMCID:2840212
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BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism reports a personality genetics study and meta-analysis on the BDNF gene val66met genetic polymorphism. In the original personality genetics study personality traits are assesed with NEO PI-R.

As a meta-analysis it extends an earlier meta-analysis Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) val66met polymorphism in anxiety disorders and anxiety-related personality traits.

Contents

[edit] Subjects

Subject group #1 (help)
Sardinians from the Lanusei Valley
Subjects/♂/♀: 1560 /  /
Age: 42.7 ±17 (14–94)
Nationality: Italian
Approval: Institutional review boards in Italy and the USA
Databases:

Group 1 of 1560 sardinians from the Lanusei Valley were included in the study. The Italian group had a mean age of 42.7 with a range from 14 to 94. The study on the human subjects was approved by the Institutional review boards in Italy and the USA.

The Sardinians (SardiNIA 2) were not overlapping with a previous study on Sardinians reported in Genome-wide association scan for five major dimensions of personality
Subject group #2 (help)
Community-dwelling Americans
Subjects/♂/♀: 1131 /  /
Age: 57.3 ±15.5 (20–93)
Nationality: American
Approval: Local institutional review board
Databases:

Group 2 of 1131 community-dwelling Americans were included in the study. The American group had a mean age of 57.3 with a range from 20 to 93. The study on the human subjects was approved by the Local institutional review board.

The community-dwelling Americans were part of the Baltimore Longitudinal Study of Aging (BLSA). See also Variants of the serotonin transporter gene and NEO-PI-R neuroticism: no association in the BLSA and SardiNIA samples.

[edit] Included studies in the meta-analysis

  1. Sen (2003). "A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression". missing journal missing volume: missing pages.
  2. Itoh (2004). "Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects". missing journal missing volume: missing pages.
  3. Undine E. Lang (2005). "Association of a functional BDNF polymorphism and anxiety-related personality traits". missing journal missing volume: missing pages.
  4. Saffron A. G. Willis-Owen (2005). "The val66met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism". missing journal missing volume: missing pages.
  5. M. Tochigi (2006). "No evidence for an association between the BDNF val66met polymorphism and schizophrenia or personality traits". Schizophr. Res. 87: 45-47.
  6. Hünnerkopf (2007). "Interaction between BDNF val66met and dopamine transporter gene variation influences anxiety-related traits". missing journal missing volume: missing pages.
  7. N. R. Wray (2008). "Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression". Psychiatr. Genet. 18: 219-225.
  8. Gatt (2009). "Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety". missing journal missing volume: missing pages.
  9. The authors previous samples.

[edit] Not included

  1. Association study of a brain-derived neurotrophic factor (BDNF) val66met polymorphism and personality trait and intelligence in healthy young females

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
BDNF met66val val/val NEO PI-R Neuroticism 55.0 9.5 707 Sardinians 20042999
BDNF met66val met/val NEO PI-R Neuroticism 55.7 9.2 694 Sardinians 20042999
BDNF met66val met/met NEO PI-R Neuroticism 55.5 8.7 159 Sardinians 20042999
BDNF met66val val/val NEO PI-R Extraversion 49.6 8.9 707 Sardinians 20042999
BDNF met66val met/val NEO PI-R Extraversion 47.5 9.4 694 Sardinians 20042999
BDNF met66val met/met NEO PI-R Extraversion 48.9 8.8 159 Sardinians 20042999
BDNF met66val val/val NEO PI-R Neuroticism 46.8 8.3 770 Community-dwelling Americans 20042999
BDNF met66val met/val NEO PI-R Neuroticism 48.3 8.6 324 Community-dwelling Americans 20042999
BDNF met66val met/met NEO PI-R Neuroticism 44.2 10.2 37 Community-dwelling Americans 20042999
BDNF met66val val/val NEO PI-R Extraversion 51.5 9.9 770 Community-dwelling Americans 20042999
BDNF met66val met/val NEO PI-R Extraversion 49.1 9.6 324 Community-dwelling Americans 20042999
BDNF met66val met/met NEO PI-R Extraversion 50.0 10.2 37 Community-dwelling Americans 20042999

Results for the community-dwelling Americans are also reported for subset consisting of only European-Americans.

[edit] Critique

  1. The association between BDNF val66met and extraversion may be driven by the heterozygotes.
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