Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females

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Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females
Authors: Akihito Suzuki, Yoshihiko Matsumoto, Shingo Oshino, Mitsuhiro Kamata, Kaoru Goto, Koichi Otani
Citation: Neuroscience Letters 439 (1): 52-55. 2008 July
Database(s): PubMed (PMID/18511195)
DOI: 10.1016/j.neulet.2008.04.088.
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Extract:

Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females reports a personality genetics study with the norepinephrine transporter gene (SLC6A2) A-3081T polymorphism and the serotonin transporter gene (SLC6A4) 5-HTTLPR with personality traits measured with the Temperament and Character Inventory.

The first author has previously published a related study on the A-3081T polymorphism: No association between the -3081A/T polymorphism in the norepinephrine transporter gene promoter and personality traits in healthy subjects

[edit] Subjects

Subject group #1 (help)
Japanee medical staff and students
Subjects/♂/♀: 575 / 296 / 279
Age: 28.7 ±9.2 (–)
Nationality: Japanese
Approval: Ethics Committee of Yamagara University School of Medicine
Databases:

Group 1 of 575 japanee medical staff and students with 296 males and 279 females were included in the study. The Japanese group had a mean age of 28.7. The study on the human subjects was approved by the Ethics Committee of Yamagara University School of Medicine.

[edit] Results

Raw average personality scores are reported with respect to haplotype and sex for the 7 scales of TCI.

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