Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention

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Paper (help)
Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention
Authors: Jonathan Scholz, Christina Triantafyllou, Susan Whitfield-Gabrieli, Emery N. Brown, Rebecca Saxe
Citation: PLOS ONE 4 (3): e4869. 2009
Database(s): PubMed (PMID/19290043)
DOI: 10.1371/journal.pone.0004869.
PMCID:2653721
Link(s): http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004869
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Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention reports a functional magnetic resonance imaging study.

Contents

[edit] Abstract from paper (CC-BY)

In functional magnetic resonance imaging (fMRI) studies, a cortical region in the right temporo-parietal junction (RTPJ) is recruited when participants read stories about people's thoughts (‘Theory of Mind’). Both fMRI and lesion studies suggest that a region near the RTPJ is associated with attentional reorienting in response to an unexpected stimulus. Do Theory of Mind and attentional reorienting recruit a single population of neurons, or are there two neighboring but distinct neural populations in the RTPJ? One recent study compared these activations, and found evidence consistent with a single common region. However, the apparent overlap may have been due to the low resolution of the previous technique. We tested this hypothesis using a high-resolution protocol, within-subjects analyses, and more powerful statistical methods. Strict conjunction analyses revealed that the area of overlap was small and on the periphery of each activation. In addition, a bootstrap analysis identified a reliable 6–10 mm spatial displacement between the peak activations of the two tasks; the same magnitude and direction of displacement was observed in within-subjects comparisons. In all, these results suggest that there are neighboring but distinct regions within the RTPJ implicated in Theory of Mind and orienting attention.

[edit] Subjects

Subject group #1 (help)
Naive adults
Subjects/♂/♀: 21 / 11 / 10
Age: (–)
Handedness: Right
Nationality: define nationality
Approval: Committee on the Use of Humans as Experimental Subjects at the Massachusetts Institute of Technology
Databases:

Group 1 of 21 right-handed naive adults with 11 males and 10 females were included in the study.

The study on the human subjects was approved by the Committee on the Use of Humans as Experimental Subjects at the Massachusetts Institute of Technology.

[edit] Scanning

MRI Scanning (help)
Mode: fMRI
Scanner: Siemens MAGNETOM Trio 3T
Type: Single shot gradient echo echo-planar imaging

(TR=2000ms, TE=30ms, FA=90°)

Slices: 21 (thickness=2mm , gap=20%mm) oriented Near-axial
Size: resolution=1.6 x 1.6mm
Laboratory: Athinoula A. Martinos Imaging Center

For fMRI Single shot gradient echo echo-planar imaging scans were acquired with a 3T Siemens MAGNETOM Trio at Athinoula A. Martinos Imaging Center.

The field of view covered the superior temporal and parietal cortices.

[edit] Results

The brain scans were analyzed with SPM2. It is not clear whether the P-values reported are corrected or uncorrected for multiple comparisons. It is not clear whether the coordinates reported are all the coordinates surviving the statistical threshold or is just the coordinate in the right temporo-parietal junction.

[edit] Theory of Mind task: "Belief versus photo"

1 coordinate in text [1]

Anatomy
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No. vox
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Coordinate search
Plot
1 Right temporo-parietal junction 60 -56 32 320 7.5 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)

[edit] Spatial attention task: "Invalid versus valid"

1 coordinate in text

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Right temporo-parietal junction 58 -62 42 16 5.9 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)
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