Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects?

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Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects?
Authors: Ina Giegling, Alberto Chiesa, Raffaella Calati, Annette M. Hartmann, Hans-Jurgen Moller, Diana De Ronchi, Dan Rujescu, Alessandro Serretti
Citation: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 150B (3): 434-438. 2009 April
Database(s): PubMed (PMID/18680103)
DOI: 10.1002/ajmg.b.30834.
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Extract:

Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects? reports a personality genetics study on rs827421, rs1913474, rs1801132, rs722207, rs974276 and rs910416 genetic polymorphisms in the ESR1 gene with personality traits assessed with the Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Healthy Germans
Subjects/♂/♀: 289 / 123 / 166
Age: 45.2 ±14.9 (–)
Nationality: German
Approval: define approval
Databases:

Group 1 of 289 healthy Germans with 123 males and 166 females were included in the study. The German group had a mean age of 45.2.

The subjects are the same as those reported in

Alessandro Serretti (2007). "5-HT2A SNPs and the Temperament and Character Inventory". Prog. Neuro-Psychopharmachol. Biol. Psychiatry 31(6): 1275-1281.

The details of the subject information is available in that paper

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
ESR1 rs722207 G/G TCI Harm avoidance 46.12 4.75 150 Healthy Germans 18680103
ESR1 rs722207 A/G TCI Harm avoidance 46.69 5.45 116 Healthy Germans 18680103
ESR1 rs722207 A/A TCI Harm avoidance 49.26 6.86 23 Healthy Germans 18680103
ESR1 rs722207 G/G TCI Anticipatory worry 13.83 1.94 150 Healthy Germans 18680103
ESR1 rs722207 A/G TCI Anticipatory worry 13.96 1.90 116 Healthy Germans 18680103
ESR1 rs722207 A/A TCI Anticipatory worry 14.28 2.06 23 Healthy Germans 18680103
ESR1 rs722207 G/G TCI Fear of uncertainty 10.43 1.46 150 Healthy Germans 18680103
ESR1 rs722207 A/G TCI Fear of uncertainty 10.65 1.57 116 Healthy Germans 18680103
ESR1 rs722207 A/A TCI Fear of uncertainty 11.47 1.85 23 Healthy Germans 18680103
ESR1 rs722207 G/G TCI Shyness with strangers 10.49 1.70 150 Healthy Germans 18680103
ESR1 rs722207 A/G TCI Shyness with strangers 10.67 1.87 116 Healthy Germans 18680103
ESR1 rs722207 A/A TCI Shyness with strangers 11.56 2.17 23 Healthy Germans 18680103
ESR1 rs722207 G/G TCI Fatigability and asthenia 11.43 1.92 150 Healthy Germans 18680103
ESR1 rs722207 A/G TCI Fatigability and asthenia 11.21 1.62 116 Healthy Germans 18680103
ESR1 rs722207 A/A TCI Fatigability and asthenia 11.55 1.64 23 Healthy Germans 18680103

[edit] Critique

  1. Biased reporting: Only personality scores for the only significant polymorphism/subject group are reported.
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