Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking

From Brede Wiki
Jump to: navigation, search
Paper (help)
Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
Authors: Richard P. Ebstein, Olga Novick, Roberto Umansky, Beatrice Priel, Yanima Osher, Darren Blaine, Estelle R. Bennett, Lubov Nemanov, Miri Katz, Robert H. Belmaker
Citation: Nature Genetics 12 (1): 78-80. 1996 January
Database(s): PubMed (PMID/8528256)
DOI: 10.1038/ng0196-78.
Link(s):
Search
Web: Bing Google Yahoo!Google PDF
Article: BASE Google Scholar PubMed
Restricted: DTU Digital Library
Other: NIF
Services
Format: BibTeX Template from PMID
Extract:

Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking reports a personality genetics study on the Exon 3 VNTR in the DRD4 gene with personality traits assessed with the Tridimensional Personality Questionnaire.

The data is analyzed in two ways: One analysis based on presence/absence of the 7 repeat allele, the other analysis based on the genotypes 4/7 and 4/4.

The study is described in the popular science book Living with our genes: why they matter more than you think.

[edit] Subjects

Subject group #1 (help)
Israeli university and hospital staff and students
Subjects/♂/♀: 124 / 69 / 55
Age: 29.8 ±8.9 (–)
Nationality: Israeli
Approval: define approval
Databases:

Group 1 of 124 israeli university and hospital staff and students with 69 males and 55 females were included in the study. The Israeli group had a mean age of 29.8.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 Exon 3 VNTR -7/-7 TPQ Novelty seeking 15.45 4.46 90 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR -7/-7 TPQ Reward dependence 18.71 3.98 90 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR -7/-7 TPQ Persistence 13.76 3.42 90 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR -7/-7 TPQ Harm avoidance 12.53 5.79 90 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 7 TPQ Novelty seeking 17.94 6.06 34 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 7 TPQ Reward dependence 19.26 4.2 34 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 7 TPQ Persistence 14.05 3.32 34 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 7 TPQ Harm avoidance 13.00 6.06 34 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/4 TPQ Novelty seeking 15.40 4.6 70 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/4 TPQ Reward dependence 18.72 4.1 70 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/4 TPQ Persistence 13.81 3.35 70 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/4 TPQ Harm avoidance 12.68 5.35 70 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/7 TPQ Novelty seeking 17.89 5.98 29 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/7 TPQ Reward dependence 18.86 4.25 29 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/7 TPQ Persistence 13.75 3.18 29 Israeli university and hospital staff and students 8528256
DRD4 Exon 3 VNTR 4/7 TPQ Harm avoidance 12.89 5.65 29 Israeli university and hospital staff and students 8528256

[edit] Related papers

  1. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking
Personal tools