Effect of COMT val158met genotype on cognition and personality

From Brede Wiki
Jump to: navigation, search
Paper (help)
Effect of COMT val158met genotype on cognition and personality
Authors: A. J. Sheldrick, A. Krug, V. Markov, D. Leube, T. M. Michel, K. Zerres, T. Eggermann, T. Kircher
Citation: European psychiatry : the journal of the Association of European Psychiatrists 23 (6): 385-389. 2008 September
Database(s): PubMed (PMID/18755576)
DOI: 10.1016/j.eurpsy.2008.05.002.
Link(s):
Search
Web: Bing Google Yahoo!Google PDF
Article: BASE Google Scholar PubMed
Restricted: DTU Digital Library
Other: NIF
Services
Format: BibTeX Template from PMID
Extract:

Effect of COMT val158met genotype on cognition and personality reports a personality genetics study on the COMT val158met genetic polymorphism with personality traits assessed with NEO-FFI and the Schizotypical Personality Questionnaire B (SPQ-B). The subjects were also assessed with the cognitive tests: D2 Test of Attention, Mehrfachwahl-Wortschatz-Inelligenztest B (MWT-B). Letter-Number-Span (LNS), Trail Making Test B (TMT-B) and Spatial span of the Wechsler Memory Scale.

[edit] Subjects

Subject group #1 (help)
Healthy Germans
Subjects/♂/♀: 522 / 267 / 255
Age: 24.75 ±5.84 (–)
Handedness: Right
Nationality: German
Approval: Local ethics committee
Databases:

Group 1 of 522 right-handed healthy Germans with 267 males and 255 females were included in the study. The German group had a mean age of 24.75. The study on the human subjects was approved by the Local ethics committee. 82.3% were Western- or Middle European descent, 6.4% Eastern European descent and 11.3% non-European descent.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
COMT met158val val/val NEO-FFI Neuroticism 1.61 0.62 129 Healthy Germans 18755576
COMT met158val met/val NEO-FFI Neuroticism 1.66 0.61 250 Healthy Germans 18755576
COMT met158val met/met NEO-FFI Neuroticism 1.56 0.65 143 Healthy Germans 18755576
COMT met158val val/val NEO-FFI Extraversion 2.38 0.48 129 Healthy Germans 18755576
COMT met158val met/val NEO-FFI Extraversion 2.36 0.44 250 Healthy Germans 18755576
COMT met158val met/met NEO-FFI Extraversion 2.4 0.46 143 Healthy Germans 18755576
COMT met158val val/val NEO-FFI Openness to experience 2.62 0.47 129 Healthy Germans 18755576
COMT met158val met/val NEO-FFI Openness to experience 2.66 0.49 250 Healthy Germans 18755576
COMT met158val met/met NEO-FFI Openness to experience 2.7 0.48 143 Healthy Germans 18755576
COMT met158val val/val NEO-FFI Agreeableness 2.63 0.49 129 Healthy Germans 18755576
COMT met158val met/val NEO-FFI Agreeableness 2.63 0.48 250 Healthy Germans 18755576
COMT met158val met/met NEO-FFI Agreeableness 2.7 0.47 143 Healthy Germans 18755576
COMT met158val val/val NEO-FFI Conscientiousness 2.74 0.56 129 Healthy Germans 18755576
COMT met158val met/val NEO-FFI Conscientiousness 2.72 0.56 250 Healthy Germans 18755576
COMT met158val met/met NEO-FFI Conscientiousness 2.72 0.57 143 Healthy Germans 18755576
COMT met158val val/val SPQ-B SPQ-B 5.03 3.38 129 Healthy Germans 18755576
COMT met158val met/val SPQ-B SPQ-B 5.42 3.78 250 Healthy Germans 18755576
COMT met158val met/met SPQ-B SPQ-B 5.66 3.6 143 Healthy Germans 18755576
COMT met158val val/val SPQ-B Cognitive-perceptual 1.61 1.48 129 Healthy Germans 18755576
COMT met158val met/val SPQ-B Cognitive-perceptual 1.75 1.48 250 Healthy Germans 18755576
COMT met158val met/met SPQ-B Cognitive-perceptual 1.78 1.57 143 Healthy Germans 18755576
COMT met158val val/val SPQ-B Interpersonal 2.2 1.77 129 Healthy Germans 18755576
COMT met158val met/val SPQ-B Interpersonal 2.22 1.87 250 Healthy Germans 18755576
COMT met158val met/met SPQ-B Interpersonal 2.12 1.88 143 Healthy Germans 18755576
COMT met158val val/val SPQ-B Disorganized 1.23 1.4 129 Healthy Germans 18755576
COMT met158val met/val SPQ-B Disorganized 1.45 1.53 250 Healthy Germans 18755576
COMT met158val met/met SPQ-B Disorganized 1.76 1.6 143 Healthy Germans 18755576
COMT met158val val/val TMT-B TMT-B 66.1 21.75 129 Healthy Germans 18755576
COMT met158val met/val TMT-B TMT-B 61.18 19.28 250 Healthy Germans 18755576
COMT met158val met/met TMT-B TMT-B 60.17 17.53 143 Healthy Germans 18755576
COMT met158val val/val WMS Spatial span 18.72 3.1 129 Healthy Germans 18755576
COMT met158val met/val WMS Spatial span 19.13 2.99 250 Healthy Germans 18755576
COMT met158val met/met WMS Spatial span 19.29 2.71 143 Healthy Germans 18755576
Personal tools