Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study

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Paper (help)
Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study
Authors: E. L. Moses, W. C. Drevets, G. Smith, C. A. Mathis, B. N. Kalro, M. A. Butters, M. P. Leondires, P. J. Greer, B. Lopresti, T. L. Loucks, S. L. Berga
Citation: Biological Psychiatry 48 (8): 854-860. 2000 October
Database(s): PubMed (PMID/11063980)
DOI: Define doi.
Link(s): http://directory.umm.ac.id/Data%20Elmu/jurnal/B/Biological%20Psichatry/Vol48.Issue8.2000/6836.pdf
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Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study resports a molecular neuroimaging study with altanserin.

[edit] Subjects

Subject group #1 (help)
Postmenopausal women

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Approval: University of Pittsburgh Biomedical Institutional Review Board.
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Group 1 of postmenopausal women were included in the study.

The study on the human subjects was approved by the University of Pittsburgh Biomedical Institutional Review Board..


[edit] Results

Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study - Table 4 - Binding potentials.csv
"Region acronym" "Baseline mean" "Baseline SD" "Post-E2 mean" "Post-E2 SD" "Post E2+P mean" "Post-E2+P SD" "Number of subjects" "Brain region"
LOF 0.84 0.15 0.89 0.23 1.01 0.15 5 "Lateral orbitofrontal cortex"
DLP 0.78 0.17 0.89 0.17 0.96 0.13 5 "Dorsolateral prefrontal cortex"
PAC 0.94 0.24 1.03 0.15 1.1 0.19 5 "Pregenual anterior cingulate cortex"
DAC 0.87 0.12 0.95 0.15 1.06 0.11 5 "Dorsal anterioal cingulate cortex"
CER 0 0 0 0 0 0 5 "Cerebellar cortex"
LTC 0.92 0.27 0.98 0.23 1.11 0.2 5 "Lateral temporal cortex"
OCC 0.99 0.15 1.04 0.18 1.13 0.15 5 "Occipital cortex"
HIP 0.24 0.2 0.29 0.23 0.29 0.2 5 Hippocampus
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[edit] Related studies

  1. Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
  2. Widespread increases of cortical serotonin type 2A receptor availability after hormone therapy in euthymic postmenopausal women
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