Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
|Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding|
|Authors:||Vibe Gedsø Frøkjær, David Erritzøe, Anders Juul, Finn Årup Nielsen, Klaus Kähler Holst, Claus Svarer, Jacob Madsen, Olaf B. Paulson, Gitte Moos Knudsen|
|Citation:||Psychoneuroendocrinology 35 (9): 1311-1320. 2010 October|
|Database(s):||CiteULike Google Scholar cites PubMed (PMID/20356681)|
|Web:||Bing Google Yahoo! — Google PDF|
|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding reports a positron emission tomography study with the F-18 altanserin radioligand for molecular neuroimaging of serotonin-2A receptor binding in healthy males.
The study finds that plasma estradiol correlates with plasma testosterone in men as well as plasma estradiol levels correlating with neocortical 5-HT2A receptor binding as assessed with the altanserin ligand.
|Subject group #1 (help)|
|Healthy Danish men|
|Subjects/♂/♀:||72 / 72 / 0|
|Age:||37.5 ±17.4 (–81.7)|
|Approval:||Local Ethics Committee, Copenhagen|
Group 1 of 72 healthy Danish men with 72 males and 0 females were included in the study. The Danish group had a mean age of 37.5. The study on the human subjects was approved by the Local Ethics Committee, Copenhagen.
The subjects overlap with:
- Adams 2004, A database of ((18)F)-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables
- Frøkjær 2008, Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
- Erritzøe 2009, Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use
- Frokjaer 2009, Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding