Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding

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Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
Authors: Vibe Gedsø Frøkjær, David Erritzøe, Anders Juul, Finn Årup Nielsen, Klaus Kähler Holst, Claus Svarer, Jacob Madsen, Olaf B. Paulson, Gitte Moos Knudsen
Citation: Psychoneuroendocrinology 35 (9): 1311-1320. 2010 October
Database(s): CiteULike Google Scholar cites PubMed (PMID/20356681)
DOI: 10.1016/j.psyneuen.2010.03.002.
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Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding reports a positron emission tomography study with the F-18 altanserin radioligand for molecular neuroimaging of serotonin-2A receptor binding in healthy males.

The study finds that plasma estradiol correlates with plasma testosterone in men as well as plasma estradiol levels correlating with neocortical 5-HT2A receptor binding as assessed with the altanserin ligand.

[edit] Subjects

Subject group #1 (help)
Healthy Danish men
Subjects/♂/♀: 72 / 72 / 0
Age: 37.5 ±17.4 (–81.7)
Nationality: Danish
Approval: Local Ethics Committee, Copenhagen
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Group 1 of 72 healthy Danish men with 72 males and 0 females were included in the study. The Danish group had a mean age of 37.5. The study on the human subjects was approved by the Local Ethics Committee, Copenhagen.

The subjects overlap with:

[edit] Related studies

  1. Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study
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