Exon 3 VNTR

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Exon 3 VNTR
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Category: Exon 3 VNTR
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Dopamine D4 receptor gene

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Exon 3 VNTR in the dopamine D4 receptor gene is a 48 base pair variable number of tandem repeats genetic polymorphism in the third exon. The region may be repeated from 2 to 11 times.[1]

Contents

[edit] Short/long

In genetic association analyses researcher often distinguish between "short" and "long" version of the repeat section. It differs slightly what researchers mean with short/long.

Short Long Reference
less or equal 4 >4 Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females
2-5 6-8 The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA)
2-5 6-8 Association of DRD4 with attention problems in normal childhood development
2-5 6-8 Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking (American)

[edit] Papers

[edit] Personality genetics

[edit] Meta-analyses

  1. Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
  2. DRD4 and novelty seeking: results of meta-analyses

[edit] "Ordinary" studies

  1. Association between dopamine D4 receptor (DRD4) exon III polymorphism and neuroticism in the Japanese population
  2. Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample
  3. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
  4. Lack of association between polymorphisms of the dopamine D4 receptor gene and personality
  5. Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population
  6. Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects
  7. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking

[edit] Extreme value design

  1. Association between the type 4 dopamine receptor gene polymorphism and novelty seeking

[edit] References

  1. Eiji Hattori (2009). "Variable number of tandem repeat polymorphisms of DRD4: re-evaluation of selection hypothesis and analysis of association with schizophrenia". European Journal of Human Genetics 17: 793-801.
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