Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder

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Paper (help)
Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder
Authors: Vibe Gedsø Frøkjær, Erik Lykke Mortensen, Finn Årup Nielsen, Steven Haugbøl, Lars Hageman Pinborg, Karen H. Adams, Claus Svarer, Steen G. Hasselbalch, Søren Holm, Olaf B. Paulson, Gitte Moos Knudsen
Citation: Biological Psychiatry 63 (6): 569-576. 2008 March
Database(s): brainspell Google Scholar cites Neurosynth PubMed (PMID/17884017)
DOI: 10.1016/j.biopsych.2007.07.009.
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Extract:

Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder describes a molecular neuroimaging study using the fluorine-18 altanserin radioligand with positron emission tomography and correlated subjects NEO PI-R Neuroticism score with the binding potential.

Contents

[edit] Subjects

Subject group (help)
Healthy volunteers
Subjects/♂/♀: 83 / 52 / 31
Age: 43 (18–76)
Nationality: Danish
Approval: Local ethics committee
Databases:

A group of 83 healthy volunteers with 52 males and 31 females were included in the study. The Danish group had a mean age of 43 with a range from 18 to 76. The study on the human subjects was approved by the Local ethics committee. There were 83 subjects included in the study. 49 of them overlapped with a previous study.[1]

[edit] Scanning

PET Scanning (help)
Scanner: GE Advance 18-ring
Radiotracer: Fluorine-18 Altanserin
Laboratory: PET and Cyclotron Unit

Using the radiotracer Fluorine-18-Altanserin PET scans were acquired with a GE Advance 18-ring at PET and Cyclotron Unit.

MRI Scanning (help)
Mode: aMRI
Scanner: Siemens Vision 1.5T
Type: MPRAGE

(TR=?, TE=?, FA=?)

Slices:
Size:
Laboratory: Danish Research Centre for Magnetic Resonance

For aMRI MPRAGE scans were acquired with a 1.5T Siemens Vision at Danish Research Centre for Magnetic Resonance.

MRI Scanning (help)
Mode: aMRI
Scanner: Siemens Trio 3T
Type: MPRAGE

(TR=?, TE=?, FA=?)

Slices:
Size:
Laboratory: Danish Research Centre for Magnetic Resonance

For aMRI MPRAGE scans were acquired with a 3T Siemens Trio at Danish Research Centre for Magnetic Resonance.

68 subjects were scanned with the 1.5T scanner while 15 where scanned with the 3T.

[edit] Result

[edit] Neuroticism

Two coordinates in Table 2.

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left insula -28 32 6 123 4.01 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Right parahippocampal gyrus 30 -22 -28 80 3.89 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Vulnerability

36 coordinates in 13 different regions listed in Table 3

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left insula and superior, middle, and inferior frontal gyrus -28 34 4 4226 5.05 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Left insula and superior, middle, and inferior frontal gyrus -26 -60 22 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left insula and superior, middle, and inferior frontal gyrus -2 52 44 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Left insula and superior, middle, and inferior frontal gyrus -48 46 0 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 Left insula and superior, middle, and inferior frontal gyrus -14 44 50 Brede Database Brede Wiki NeuroSynth SumsDB Not available
6 Left insula and superior, middle, and inferior frontal gyrus -4 66 12 Brede Database Brede Wiki NeuroSynth SumsDB Not available
7 Left insula and superior, middle, and inferior frontal gyrus -4 62 26 Brede Database Brede Wiki NeuroSynth SumsDB Not available
8 Left insula and superior, middle, and inferior frontal gyrus -40 8 60 Brede Database Brede Wiki NeuroSynth SumsDB Not available
9 Left insula and superior, middle, and inferior frontal gyrus -30 40 -16 Brede Database Brede Wiki NeuroSynth SumsDB Not available
10 Right superior frontal gyrus, orbital, and dorsolateral part 2 62 -14 2402 4.54 Brede Database Brede Wiki NeuroSynth SumsDB Not available
11 Right superior frontal gyrus, orbital, and dorsolateral part 16 56 36 Brede Database Brede Wiki NeuroSynth SumsDB Not available
12 Left superior temporal gyrus -66 -22 18 Brede Database Brede Wiki NeuroSynth SumsDB Not available
13 Left superior temporal gyrus -62 -2 20 Brede Database Brede Wiki NeuroSynth SumsDB Not available
14 Left superior temporal gyrus -58 10 .14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
15 Left superior temporal gyrus -66 -48 16 Brede Database Brede Wiki NeuroSynth SumsDB Not available
16 Left superior temporal gyrus -46 2 -14 Brede Database Brede Wiki NeuroSynth SumsDB Not available
17 Left superior temporal gyrus -64 -8 2 Brede Database Brede Wiki NeuroSynth SumsDB Not available
18 Left superior temporal gyrus -60 -26 42 Brede Database Brede Wiki NeuroSynth SumsDB Not available
19 Right inferior, orbital, and middle frontal gyrus 46 52 12 1445 4.56 Brede Database Brede Wiki NeuroSynth SumsDB Not available
20 Right inferior, orbital, and middle frontal gyrus 54 32 24 Brede Database Brede Wiki NeuroSynth SumsDB Not available
21 Right inferior, orbital, and middle frontal gyrus 54 32 24 Brede Database Brede Wiki NeuroSynth SumsDB Not available
22 Right inferior, orbital, and middle frontal gyrus 30 62 -6 Brede Database Brede Wiki NeuroSynth SumsDB Not available
23 Left occipital and posterior cingulate -22 -62 36 712 4.19 Brede Database Brede Wiki NeuroSynth SumsDB Not available
24 Left occipital and posterior cingulate -12 -48 24 Brede Database Brede Wiki NeuroSynth SumsDB Not available
25 Right fusiform gyrus 32 -18 -30 570 4.70 Brede Database Brede Wiki NeuroSynth SumsDB Not available
26 Right precuneus 24 -56 30 257 3.86 Brede Database Brede Wiki NeuroSynth SumsDB Not available
27 Right precuneus 16 -52 26 Brede Database Brede Wiki NeuroSynth SumsDB Not available
28 Right superior frontal gyrus; dorsolateral 36 -4 64 247 3.81 Brede Database Brede Wiki NeuroSynth SumsDB Not available
29 Right superior frontal gyrus; dorsolateral 22 24 62 Brede Database Brede Wiki NeuroSynth SumsDB Not available
30 Right superior temporal pole 60 8 -4 3.97 Brede Database Brede Wiki NeuroSynth SumsDB Not available
31 Right superior temporal pole 64 0 10 247 Brede Database Brede Wiki NeuroSynth SumsDB Not available
32 Left fusiform gyrus -30 -20 -32 212 3.88 Brede Database Brede Wiki NeuroSynth SumsDB Not available
33 Right superior temporal gyrus 68 -28 12 54 3.68 Brede Database Brede Wiki NeuroSynth SumsDB Not available
34 Left middle temporal pole -36 22 -32 13 3.65 Brede Database Brede Wiki NeuroSynth SumsDB Not available
35 Right middle temporal gyrus 66 -50 -4 12 3.48 Brede Database Brede Wiki NeuroSynth SumsDB Not available
36 Left middle temporal gyrus -44 -48 8 12 3.52 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Critique

  1. P-values are on uncorrected levels, — neither corrected across voxels nor personality traits.

[edit] References

  1. Karen H. Adams, Lars Hageman Pinborg, Claus Svarer, Steen G. Hasselbalch, Søren Holm (2004). "A database of 18F-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables". NeuroImage 21: 1105-1113.
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