Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population

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Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population
Authors: Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima
Citation: Neuroscience Research 64 (2): 231-234. 2009 June
Database(s): PubMed (PMID/19428704)
DOI: 10.1016/j.neures.2009.03.003.
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Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population reports a genetic association study with polymorphisms in the HTR2A gene and the mood disorders: bipolar disorder and major depressive disorder. With 325 MDD patient, 155 BP patients and 802 control subjects they can detect no association.

The investigated polymorphisms are:

  1. rs6313, exon 1
  2. rs1928040, intron 2
  3. rs2070040, intron 1
  4. rs7997012, intron 2

They find no major effect between the HTR2A polymorphisms and either major depressive disorder nor bipolar disorder.

[edit] Subjects

Subject group #1 (help)
Major depressive disorder patients
Subjects/♂/♀: 325 / 159 / 166
Age: (–)
Nationality: Japanese
Approval: define approval
Databases:
Group 1 of 325 major depressive disorder patients with 159 males and 166 females were included in the study.
Subject group #2 (help)
Bipolar disorder patients
Subjects/♂/♀: 155 / 80 / 75
Age: (–)
Nationality: Japanese
Approval: define approval
Databases:
Group 2 of 155 bipolar disorder patients with 80 males and 75 females were included in the study.
Subject group #3 (help)
Major depressive disorder patients
Subjects/♂/♀: 802 / 351 / 451
Age: (–)
Nationality: Japanese
Approval: define approval
Databases:

Group 3 of 802 major depressive disorder patients with 351 males and 451 females were included in the study.


Of the bipolar disorder patients 96 has bipolar disorder I and 59 had bipolar disorder II.

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