Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis

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Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis
Authors: Marcus R. Munafò, T. G. Clark, L. R. Moore, E. Payne, R. Walton, Jonathan Flint
Citation: Molecular Psychiatry 8 (5): 471-474. 2003 May
Database(s): PubMed (PMID/12808427)
DOI: 10.1038/sj.mp.4001326.
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Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis reports a meta-analysis on personality genetics studies. The authors found 79 studies. Of these 33 studies was not meta-anlyzed due to different reasons. 46 did go into the meta-analysis with 22 studies on 5-HTTLPR, 17 on DRD4 exon 3 VNTR, 5 on DRD4 C-521T, 6 on DRD2 A1/A2, 4 on DRD3 A1/A2 and 4 on DAT (SLC6A3) 40-bp VNTR.

There should be supplementary material available, e.g., with data from Table 3 available graphically (p. 473 col. 2), but on the homepage there is no such link.

[edit] Genes examined

  1. AD 1a
  2. AD 2a
  3. AR
  4. COMT
  5. DRD2
  6. DRD3[1]
  7. DRD4
  8. HTR2A (5HT 2a)
  9. HTR2C (5HT 2c)
  10. NET
  11. MAOA (MAO)[2]
  12. SLC6A3 (DAT)[3][4][5][6]
  13. SLC6A4 5-HTTLPR (5HTT)
  14. TH[7]
  15. TPH

[edit] References

  1. Henderson (2000). "COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders". missing journal missing volume: missing pages.
  2. S. B. Manuck (2000). "A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity". Psychiatry Res. 95: 9-23.
  3. C. H. D. Bau (2001). "DRD4 and DAT1 as modifying genes in alcoholism: interaction with novelty seeking on level of alcohol consumption". Mol. Psychiatry 6: 7-9.
  4. Comings (2000). "The DRD4 gene and the spiritual transcendence scale of the character temperament index". Psychiatr. Genet. 10: 185-189.
  5. Sabol (1999). "A genetic association for cigarette smoking behavior". Health Psychol. 18: 7-13.
  6. Samochowiec (2001). "Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers". Neuropsychobiology 43: 248-253.
  7. D. A. Nielsen (1998). "A tryptophan hydroxylase gene marker for suicidality and alcoholism". Archives of General Psychiatry 55: 593-602.
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