Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality

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Paper (help)
Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
Authors: J. W. Buckholtz, J. H. Callicott, B. Kolachana, Ahmad R. Hariri, T. E. Goldberg, M. Genderson, M. F. Egan, Venkata S. Mattay, Daniel R. Weinberger, Andreas Meyer-Lindenberg
Citation: Molecular psychiatry 13 (3): 313-314. 2008 March
Database(s): PubMed (PMID/17519928)
DOI: 10.1038/sj.mp.4002020.
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Extract:

Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality reports a personality genetics study on the MAOA-uVNTR genetic polymorphism and personality traits assessed with the Tridimensional Personality Questionnaire.

The MAOA-uVNTR genotypes were classified into

  • Low: 3 or 5 repeats
  • High: 3.5 or 4 repeats

Two individuals had the 2 repeat allele.

[edit] Subjects

Subject group (help)
Healthy Caucasian American
Subjects/♂/♀: 123 / 60 / 63
Age: 29.23 (–)
Nationality: American
Approval: define approval
Databases:

A group of 123 healthy Caucasian American with 60 males and 63 females were included in the study. The American group had a mean age of 29.23.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
MAOA uVNTR 3 5 TPQ Harm avoidance 9.84 4.89 49 Healthy Caucasian Americans 17519928
MAOA uVNTR 3.5 4 TPQ Harm avoidance 8.52 4.73 74 Healthy Caucasian Americans 17519928
MAOA uVNTR 3 5 TPQ Novelty seeking 16.22 4.3 49 Healthy Caucasian Americans 17519928
MAOA uVNTR 3.5 4 TPQ Novelty seeking 15.08 4.29 74 Healthy Caucasian Americans 17519928
MAOA uVNTR 3 5 TPQ Reward dependence 19.71 3.35 49 Healthy Caucasian Americans 17519928
MAOA uVNTR 3.5 4 TPQ Reward dependence 19.84 3.61 74 Healthy Caucasian Americans 17519928

[edit] Criticism

  1. It is unclear how the heterozygotes are classified: They are either in the 'low' or 'high' group
  2. The type of intelligence test seems not to be mentioned.
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