Hippocampal structural changes across the menstrual cycle

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Paper (help)
Hippocampal structural changes across the menstrual cycle
Authors: Xenia Protopopescu, Tracy Butler, Hong Pan, James Root, Margaret Altemus, Margaret Polanecsky, Bruce McEwen, David Silbersweig, Emily Stern
Citation: Hippocampus 18 (10): 985-988. 2008
Database(s): PubMed (PMID/18767068)
DOI: 10.1002/hipo.20468.
Link(s): http://functionalneurolab.files.wordpress.com/2009/01/protopopescu_etal_2008.pdf
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Hippocampal structural changes across the menstrual cycle reports a voxel-based morphometry with magnetic resonance imaging with women scanned premenstrual and postmenstrual.

This study was blogged by Thomas Ramsøy.[1]

Contents

[edit] Subjects

Subject group #1 (help)
Women
Subjects/♂/♀: 21 / 0 / 21
Age: 29 (22–35)
Nationality: define nationality
Approval: define approval
Databases:

Group 1 of 21 women with 0 males and 21 females were included in the study. The group had a mean age of 29 with a range from 22 to 35.

The women were scanned twice, and the participant were both with and without premenstrual symptoms.

[edit] Scanning

MRI Scanning (help)
Mode: sMRI
Scanner: GE Sigma 3T
Type: T1-weighted Spoiled gradient recalled

(TR=30ms, TE=8ms, FA=45°)

Slices: 100
Size: FOV=240mm matrix=256 x 256 resolution=0.9375 x 0.9375 x 1.5mm
Laboratory: missing laboratory

For sMRI T1-weighted Spoiled gradient recalled scans were acquired with a 3T GE Sigma.


[edit] Results

[edit] Postmenstruel versus premenstrual


Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left occipital, lingual gyrus 18 -6 -80 -16 3.62 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Right hippocampus/parahippocampus 20 -8 -22 3.33 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left middle frontal gyrus -42 16 44 3.42 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Premenstrual versus postmenstrual


Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left superior parietal lobule 7 -22 -54 66 -3.88 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Rigth dorsal basal ganglia (globus pallidus/putamen) 18 -4 4 3.74 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Right medial frontal gyrus/anterior cingulate 16 -4 54 3.38 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Right thalamus (pulvinar) 26 -30 8 3.05 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Critique

The statistical values are rather low, and it seems that uncorrected P-values were used. Some specific points are:

  1. The text states that a threshold on "0.001" was selected (page 986), while Table 1 caption has "<0.005"
  2. It is not clear whether the states voxel-wise P-value is corrected for multiple comparison or not.
  3. A heterogeneous statistical threshold is selected across the brain so that P=0.001 and a spatial extent threshold on 0.5 cm3 are generally used while "a priori" regions where defined in the anterior hippocampus and dorsal basal ganglia. Within the "a priori" brain region the p-values were considered significant if below 0.05 corrected.
  4. Even though there is a spatial extent threshold on 0.5 cm3 the authors reports regions below that threshold (though mark them as so).

[edit] References

  1. Thomas Z. Ramsøy (2008-10-7). Hippocampus throughout the menstrual cycle Brainethics.
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