Hippocampal structural changes across the menstrual cycle reports a voxel-based morphometry with magnetic resonance imaging with women scanned premenstrual and postmenstrual.
This study was blogged by Thomas Ramsøy.
|Subject group #1 (help)
||21 / 0 / 21
Group 1 of 21 women with 0 males and 21 females were included in the study.
The group had a mean age of 29 with a range from 22 to 35.
The women were scanned twice, and the participant were both with and without premenstrual symptoms.
|MRI Scanning (help)
||GE Sigma 3T
||T1-weighted Spoiled gradient recalled
(TR=30ms, TE=8ms, FA=45°)
||FOV=240mm matrix=256 x 256 resolution=0.9375 x 0.9375 x 1.5mm
For sMRI T1-weighted Spoiled gradient recalled scans were acquired with a 3T GE Sigma.
 Postmenstruel versus premenstrual
 Premenstrual versus postmenstrual
The statistical values are rather low, and it seems that uncorrected P-values were used.
Some specific points are:
- The text states that a threshold on "0.001" was selected (page 986), while Table 1 caption has "<0.005"
- It is not clear whether the states voxel-wise P-value is corrected for multiple comparison or not.
- A heterogeneous statistical threshold is selected across the brain so that P=0.001 and a spatial extent threshold on 0.5 cm3 are generally used while "a priori" regions where defined in the anterior hippocampus and dorsal basal ganglia. Within the "a priori" brain region the p-values were considered significant if below 0.05 corrected.
- Even though there is a spatial extent threshold on 0.5 cm3 the authors reports regions below that threshold (though mark them as so).
- ↑ Thomas Z. Ramsøy (2008-10-7). Hippocampus throughout the menstrual cycle Brainethics.