Homosexual women have less grey matter in perirhinal cortex than heterosexual women

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Homosexual women have less grey matter in perirhinal cortex than heterosexual women
Authors: Jorge Ponseti, Hartwig Roman Siebner, Stefan Kloppel, Stephan Wolff, Oliver Granert, Olav Jansen, Hubertus M. Mehdorn, Hartmut A. Bosinski
Citation: PloS one 2 (1): e762. 2007
Database(s): brainspell Neurosynth PubMed (PMID/17712410)
DOI: 10.1371/journal.pone.0000762.
PMCID:1942120
Link(s): http://www.plosone.org/article/fetchObjectAttachment.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0000762&representation=PDF
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Extract: Talairach coordinates from linked PDF: CSV-formated wiki-formated

Homosexual women have less grey matter in perirhinal cortex than heterosexual women is a study with structure magnetic resonance imaging with voxel-based morphometry for studying grey matter concentration among homosexual and heterosexual women.

Contents

[edit] Abstract from Ponseti et al. (CC-by)

Is sexual orientation associated with structural differences in the brain? To address this question, 80 homosexual and heterosexual men and women (16 homosexual men and 15 homosexual women) underwent structural MRI. We used voxel-based morphometry to test for differences in grey matter concentration associated with gender and sexual orientation. Compared with heterosexual women, homosexual women displayed less grey matter bilaterally in the temporo-basal cortex, ventral cerebellum, and left ventral premotor cortex. The relative decrease in grey matter was most prominent in the left perirhinal cortex. The left perirhinal area also showed less grey matter in heterosexual men than in heterosexual women. Thus, in homosexual women, the perirhinal cortex grey matter displayed a more male-like structural pattern. This is in accordance with previous research that revealed signs of sex-atypical prenatal androgenization in homosexual women, but not in homosexual men. The relevance of the perirhinal area for high order multimodal (olfactory and visual) object, social, and sexual processing is discussed.

[edit] Results

[edit] Areas of increased GM concentration in heterosexual women compared to homosexual women

Table 2 with 5 Talairach coordinates [1].

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Left perirhinal cortex -32 1 -35 1209 6.20 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Left ventral premotor cortex -63 3 36 101 5.37 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left cerebellum -10 -40 -55 744 5.37 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Right cerebellum 26 -50 -59 303 4.74 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 Right perirhinal cortex 34 3 -36 240 4.61 Brede Database Brede Wiki NeuroSynth SumsDB Not available

[edit] Related studies

  1. A functional endophenotype for sexual orientation in humans
  2. PET and MRI show differences in cerebral asymmetry and functional connectivity between homo- and heterosexual subjects
  3. Regional gray matter variation in male-to-female transsexualism
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