Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait

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Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait
Authors: Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe, T. Arinami
Citation: Molecular Psychiatry 5 (1): 64-69. 2000 January
Database(s): PubMed (PMID/10673770)
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Identification of a polymorphism in the promoter region of the DRD4 associated with the human novelty seeking personality trait reports a personality genetics study on the DRD4 gene and the C-521T genetic polymorphism.

Both these meta-analyses support the studies finding of the association between DRD4 C-521T and novelty seeking.

[edit] Subjects

Subject group #1 (help)
Male Japanese university staff and students
Subjects/♂/♀: 86 / 86 / 0
Age: 22.8 (18–29)
Nationality: Japanese
Approval: define approval
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Group 1 of 86 male Japanese university staff and students with 86 males and 0 females were included in the study. The Japanese group had a mean age of 22.8 with a range from 18 to 29.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 C-521T C/C TCI Novelty seeking 25.1 4.5 28 Male Japanese university staff and students 10673770
DRD4 C-521T C/C TCI Harm avoidance 18.0 7.2 28 Male Japanese university staff and students 10673770
DRD4 C-521T C/C TCI Reward dependence 14.5 3.7 28 Male Japanese university staff and students 10673770
DRD4 C-521T C/C TCI Persistence 3.5 1.7 28 Male Japanese university staff and students 10673770
DRD4 C-521T C/T TCI Novelty seeking 21.7 4.2 36 Male Japanese university staff and students 10673770
DRD4 C-521T C/T TCI Harm avoidance 16.7 5.8 36 Male Japanese university staff and students 10673770
DRD4 C-521T C/T TCI Reward dependence 14.9 3.5 36 Male Japanese university staff and students 10673770
DRD4 C-521T C/T TCI Persistence 4.9 1.7 36 Male Japanese university staff and students 10673770
DRD4 C-521T T/T TCI Novelty seeking 19.1 5.6 22 Male Japanese university staff and students 10673770
DRD4 C-521T T/T TCI Harm avoidance 20.9 7.4 22 Male Japanese university staff and students 10673770
DRD4 C-521T T/T TCI Reward dependence 14.8 3.6 22 Male Japanese university staff and students 10673770
DRD4 C-521T T/T TCI Persistence 4.8 2.1 22 Male Japanese university staff and students 10673770


[edit] Critique

  1. Biased reporting: six polymorphisms were investigated, but only data for the significant polymorphims were reported.
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