Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism

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Paper (help)
Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism
Authors: Martin P. Paulus, Corianne Rogalsky, Alan Simmons, Justin S. Feinstein, Murray B. Stein
Citation: NeuroImage 19 : 1439-1448. 2003
Database(s): PubMed (PMID/12948701)
DOI: 10.1016/S1053-8119(03)00251-9.
Link(s): http://koso.ucsd.edu/~martin/PaulusRiskNeuroimage2003.pdf
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Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism reports a functional magnetic resonance imaging study on healthy subjects and with personality assessment.

Contents

[edit] Subject

Subject group (help)
Healthy
Description: Healthy, right-handed subjects
Subjects/♂/♀: 17 / 11 / 6
Age: 38.3 ±1.4 (27–53)
Nationality: American
Approval: UCSD Human Research Protection Program
Databases:

A group of 17 healthy with 11 males and 6 females were included in the study. The American group had a mean age of 38.3 with a range from 27 to 53. The study on the human subjects was approved by the UCSD Human Research Protection Program. The subjects participated under approval of UCSD Human Research Protection Program.

All subjects completed Temperament and Character Inventory and NEO-FFI questionnaires.

(There is a rather little standard deviation on the age compared to the max age)

[edit] Results

Results were obtained with AFNI and the cluster-size threshold based on Forman and others.[1] So seemingly the P-values are corrected on the cluster level with <0.05(!?).

[edit] Risky versus safe response

Table I with 5 coordinates on page 1444.

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Right insula 13 32 18 7 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Left cuneus 7 -7 -74 32 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left precuneus 7 -17 -70 40 Brede Database Brede Wiki NeuroSynth SumsDB Not available
4 Right precuneus 7 10 -65 27 Brede Database Brede Wiki NeuroSynth SumsDB Not available
5 Right middle frontal gyrus 9 37 7 33 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)

[edit] Risky versus punished trials

Table 2 with 3 coordinates on page 1444.

Anatomy
BA
x
y
z
No. vox
t
z
Coordinate search
Plot
1 Right inferior frontal gyrus/insula 44/13 48 4 18 Brede Database Brede Wiki NeuroSynth SumsDB Not available
2 Left superior frontal lobule 7 -24 -47 55 Brede Database Brede Wiki NeuroSynth SumsDB Not available
3 Left insula 13 -38 -21 15 Brede Database Brede Wiki NeuroSynth SumsDB Not available
Entry not completed (help)

[edit] References

  1. S. D. Forman, J. D. Cohen, M. Fitzgerald, W. F. Eddy, M. A. Mintun, D. C. Noll (1995). "Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold". Magnetic Resonance in Medicine 33: 636-547.
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