Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis
|Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis|
|Authors:||Neil Risch, Richard Herrell, Thomas Lehner, Kung-Yee Liang, Lindon Eaves, Josephine Hoh, Andrea Griem, Maria Kovacs, Jurg Ott, Kathleen Ries Merikangas|
|Citation:||JAMA : the journal of the American Medical Association 301 (23): 2462-2461. 2009 June|
|Web:||Bing Google Yahoo! — Google PDF|
|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis reports a meta-analysis on the 5-HTTLPR polymorphism, stressful life events and depression.
There is a erratum which corrects wording in the original article.
There was a number of comments on the article:
- K. C. Koenen, S. Galea, Gene-environment interactions and depression
- N. Rieckmann, M. A. Rapp, J. Müller-Nordhorn, Gene-environment interactions and depression
- Gene-environment interactions: biologically valid pathway or artifact?
- Jacob Peedicayil pointed to epigenetics as an explanation for gene-environment (GXE) interactions.
The study Gene x environment interactions at the serotonin transporter locus also examined 5-HTTLPR and stressful life event interaction on depression.
A newer study claims association The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.
 Included studies
- Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
- Gene-environment interaction analysis of serotonin system markers with adolescent depression
- The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression
- Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden
- Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder
- Life events, first depression onset and the serotonin transporter gene
- Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology
- Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample
- Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression
- No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys
- PREDICT Study Core Group. The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort
- Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders
- 5-HTTLPR genotype, stressful life events and late-life depression: no evidence of interaction in a French population
- Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: evidence from a high-risk community sample of young adults
The three main results were :
- No association of 5-HTTLPR on depression
- Association of stressful life events and depression
- No association of interaction between 5-HTTLPR and stressful life events on depression
- ↑ missing author1 (2009). "Incorrect Wording in: Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis". JAMA 302(5): 492. doi: 10.1001/jama.302.5.492.
- ↑ Jacob Peedicayi (2009). "The role of epigenetics in gene-environment interactions". Arch. Gen. Psychiatry 66: 1287-1289. .