Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
|Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety|
|Authors:||Justine M. Gatt, C. B. Nemeroff, Carol Dobson-Stone, R. H. Paul, R. A. Bryant, P. R. Schofield, E. Gordon, Andrew H. Kemp, L. M. Williams|
|Citation:||Molecular psychiatry 14 (7): 681-685. 2009 July|
|Web:||Bing Google Yahoo! — Google PDF|
|Article:||BASE Google Scholar PubMed|
|Restricted:||DTU Digital Library|
|Format:||BibTeX Template from PMID|
Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety reports a personality genetics study on the val66met genetic polymorphism in the BDNF gene.
There are supplementary material for the paper: .
- The study is included in the meta-analysis BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism.
|Subject group #1 (help)|
|Healthy Caucasian Australians|
|Subjects/♂/♀:||374 / / 190|
|Age:||36.2 ±12.7 (–)|
Group 1 of 374 healthy Caucasian Australians were included in the study. The Australian group had a mean age of 36.2.
The subjects participated in the collaboration with the Brain Resource International Database.
 ResultsRaw personality scores across genotypes are available in the Supplementary Table 5 for neuroticism.
|BDNF||met66val||val/val||DASS21||Depression||4.34||5.94||242||Healthy Caucasian Australians||19153574|
|BDNF||met66val||met||DASS21||Depression||3.97||4.88||132||Healthy Caucasian Australians||19153574|
|BDNF||met66val||val/val||DASS21||Anxiety||2.14||3.31||242||Healthy Caucasian Australians||19153574|
|BDNF||met66val||met||DASS21||Anxiety||1.95||2.94||132||Healthy Caucasian Australians||19153574|
|BDNF||met66val||val/val||NEO-FFI||Neuroticism||19.02||7.37||242||Healthy Caucasian Australians||19153574|
|BDNF||met66val||met||NEO-FFI||Neuroticism||18.19||7.40||132||Healthy Caucasian Australians||19153574|