Lack of association between polymorphisms of the dopamine D4 receptor gene and personality

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Paper (help)
Lack of association between polymorphisms of the dopamine D4 receptor gene and personality
Authors: Alexander Strobel, Frank M. Spinath, Alois Angleitner, Rainer Riemann, Klaus-Peter Lesch
Citation: Neuropsychobiology 47 (1): 52-56. 2003
Database(s): PubMed (PMID/12606846)
DOI: 10.1159/000068876.
Link(s): http://psychobiologie.uni-wuerzburg.de/publications/pdf/strobeletal2003lack.pdf
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Lack of association between polymorphisms of the dopamine D4 receptor gene and personality reports a personality genetics study on exon 3 VNTR and C-521T genetic polymorphisms in the DRD4 gene and personality traits assessed with NEO-FFI.

[edit] Subjects

Subject group #1 (help)
Healthy unrelated German twins
Subjects/♂/♀: 115 / 29 / 86
Age: 33.0 ±12.4 (18–67)
Nationality: German
Approval: define approval
Databases:

Group 1 of 115 healthy unrelated German twins with 29 males and 86 females were included in the study. The German group had a mean age of 33.0 with a range from 18 to 67.

The subjects was a sample from German Observational Study of Adult Twins (GOSAT).

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 Exon 3 VNTR -7/-7 NEO-FFI Neuroticism 31.7 7.6 75 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR -7/-7 NEO-FFI Extraversion 43.3 6.3 75 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR -7/-7 NEO-FFI Openness to experience 41.9 5.6 75 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR -7/-7 NEO-FFI Agreeableness 45.0 4.9 75 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR -7/-7 NEO-FFI Conscientiousness 45.9 6.4 75 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR 7 NEO-FFI Neuroticism 33.5 8.8 40 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR 7 NEO-FFI Extraversion 42.4 7.6 40 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR 7 NEO-FFI Openness to experience 41.9 7.0 40 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR 7 NEO-FFI Agreeableness 45.1 5.4 40 Healthy unrelated German twins 12606846
DRD4 Exon 3 VNTR 7 NEO-FFI Conscientiousness 44.9 7.4 40 Healthy unrelated German twins 12606846
DRD4 C-521T T/T NEO-FFI Neuroticism 33.1 8.7 47 Healthy unrelated German twins 12606846
DRD4 C-521T T/T NEO-FFI Extraversion 43.1 6.2 47 Healthy unrelated German twins 12606846
DRD4 C-521T T/T NEO-FFI Openness to experience 41.5 6.8 47 Healthy unrelated German twins 12606846
DRD4 C-521T T/T NEO-FFI Agreeableness 44.5 5.5 47 Healthy unrelated German twins 12606846
DRD4 C-521T T/T NEO-FFI Conscientiousness 44.0 6.7 47 Healthy unrelated German twins 12606846
DRD4 C-521T C/T NEO-FFI Neuroticism 31.8 7.7 44 Healthy unrelated German twins 12606846
DRD4 C-521T C/T NEO-FFI Extraversion 42.3 7.8 44 Healthy unrelated German twins 12606846
DRD4 C-521T C/T NEO-FFI Openness to experience 42.1 6.1 44 Healthy unrelated German twins 12606846
DRD4 C-521T C/T NEO-FFI Agreeableness 45.4 4.3 44 Healthy unrelated German twins 12606846
DRD4 C-521T C/T NEO-FFI Conscientiousness 46.6 6.3 44 Healthy unrelated German twins 12606846
DRD4 C-521T C/C NEO-FFI Neuroticism 31.9 7.5 24 Healthy unrelated German twins 12606846
DRD4 C-521T C/C NEO-FFI Extraversion 44.2 5.7 24 Healthy unrelated German twins 12606846
DRD4 C-521T C/C NEO-FFI Openness to experience 42.1 4.7 24 Healthy unrelated German twins 12606846
DRD4 C-521T C/C NEO-FFI Agreeableness 45.3 5.4 24 Healthy unrelated German twins 12606846
DRD4 C-521T C/C NEO-FFI Conscientiousness 46.4 7.4 24 Healthy unrelated German twins 12606846
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