Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms

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Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms
Authors: Erik G. Jönsson, Markus M. Nothen, J. Petter Gustavsson, Helge Neidt, Stefan Brene, Alexandra Tylec, Peter Propping, Göran C. Sedvall
Citation: The American journal of psychiatry 154 (5): 697-699. 1997 May
Database(s): PubMed (PMID/9137132)
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Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms reports a personality genetics study on exon 3 VNTR, 13-bp deletion, 12-bp repeat genetic polymorphisms in the DRD4 gene with personality traits assessed with the Karolinska Scales of Personality.


Contents

[edit] Subjects

Subject group #1 (help)
Caucasian Swedes
Subjects/♂/♀: 126 / 76 / 50
Age: 41 ±8 (25–61)
Nationality: Swedish
Approval: Ethics Committee of the Karolinska Hospital
Databases:

Group 1 of 126 caucasian Swedes with 76 males and 50 females were included in the study. The Swedish group had a mean age of 41 with a range from 25 to 61. The study on the human subjects was approved by the Ethics Committee of the Karolinska Hospital.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 Exon 3 VNTR short KSP Impulsiveness 50.5 9.0 85 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR short KSP Monotony avoidance 54.0 10.9 85 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR short KSP Solidity 47.1 7.1 85 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR short KSP Socialization 47.1 10.0 85 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR short KSP Guilt 47.0 9.0 85 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR long KSP Impulsiveness 53.0 8.7 41 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR long KSP Monotony avoidance 56.0 9.4 41 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR long KSP Solidity 48.6 6.6 41 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR long KSP Socialization 48.6 9.7 41 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR long KSP Guilt 46.2 8.3 41 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR -7/-7 KSP Impulsiveness 50.9 9.2 87 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR -7/-7 KSP Monotony avoidance 54.2 11.0 87 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR -7/-7 KSP Solidity 47.4 7.2 87 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR -7/-7 KSP Socialization 47.3 10.1 87 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR -7/-7 KSP Guilt 47.1 9.1 87 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 7 KSP Impulsiveness 52.4 8.5 39 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 7 KSP Monotony avoidance 55.6 9.3 39 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 7 KSP Solidity 48.1 6.3 39 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 7 KSP Socialization 48.1 9.7 39 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 7 KSP Guilt 45.9 7.8 39 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/4 KSP Impulsiveness 51.3 9.1 55 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/4 KSP Monotony avoidance 52.6 11.6 55 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/4 KSP Solidity 47.0 7.3 55 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/4 KSP Socialization 46.9 10.9 55 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/4 KSP Guilt 47.9 9.4 55 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/7 KSP Impulsiveness 52.3 8.4 34 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/7 KSP Monotony avoidance 56.1 9.7 34 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/7 KSP Solidity 48.4 6.6 34 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/7 KSP Socialization 47.7 9.1 34 Caucasian Swedes 9137132
DRD4 Exon 3 VNTR 4/7 KSP Guilt 46.2 8.0 34 Caucasian Swedes 9137132
DRD4 12-bp repeat 1 KSP Impulsiveness 50.4 13.2 14 Caucasian Swedes 9137132
DRD4 12-bp repeat 1 KSP Monotony avoidance 52.7 10.7 14 Caucasian Swedes 9137132
DRD4 12-bp repeat 1 KSP Solidity 46.4 9.4 14 Caucasian Swedes 9137132
DRD4 12-bp repeat 1 KSP Socialization 47.3 12.0 14 Caucasian Swedes 9137132
DRD4 12-bp repeat 1 KSP Guilt 46.0 9.9 14 Caucasian Swedes 9137132
DRD4 12-bp repeat 2/2 KSP Impulsiveness 51.5 8.3 112 Caucasian Swedes 9137132
DRD4 12-bp repeat 2/2 KSP Monotony avoidance 54.9 10.4 112 Caucasian Swedes 9137132
DRD4 12-bp repeat 2/2 KSP Solidity 47.8 6.6 112 Caucasian Swedes 9137132
DRD4 12-bp repeat 2/2 KSP Socialization 47.6 9.7 112 Caucasian Swedes 9137132
DRD4 12-bp repeat 2/2 KSP Guilt 46.8 8.6 112 Caucasian Swedes 9137132
DRD4 13-bp deletion ins/ins KSP Impulsiveness 51.4 9.0 117 Caucasian Swedes 9137132
DRD4 13-bp deletion ins/ins KSP Monotony avoidance 54.6 10.6 117 Caucasian Swedes 9137132
DRD4 13-bp deletion ins/ins KSP Solidity 47.6 7.0 117 Caucasian Swedes 9137132
DRD4 13-bp deletion ins/ins KSP Socialization 48.2 9.6 117 Caucasian Swedes 9137132
DRD4 13-bp deletion ins/ins KSP Guilt 46.2 8.5 117 Caucasian Swedes 9137132
DRD4 13-bp deletion del KSP Impulsiveness 51.0 8.6 9 Caucasian Swedes 9137132
DRD4 13-bp deletion del KSP Monotony avoidance 55.4 8.8 9 Caucasian Swedes 9137132
DRD4 13-bp deletion del KSP Solidity 47.8 6.5 9 Caucasian Swedes 9137132
DRD4 13-bp deletion del KSP Socialization 39.1 10.4 9 Caucasian Swedes 9137132
DRD4 13-bp deletion del KSP Guilt 55.0 9.0 9 Caucasian Swedes 9137132

[edit] Related papers

  1. Lack of association between dopamine D4 receptor gene and personality traits

[edit] Critique

  1. It is not entirely clear what "short" and "long" means wrt. the heterozygotes.
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