No association between dopamine D4 receptor gene variants and novelty seeking

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Paper (help)
No association between dopamine D4 receptor gene variants and novelty seeking
Authors: Erik G. Jönsson, R. Ivo, J. P. Gustavsson, T. Geijer, K. Forslund, M. Mattila-Evenden, G. Rylander, S. Cichon, P. Propping, H. Bergman, M. Åsberg, M. M. Nothen
Citation: Molecular psychiatry 7 (1): 18-20. 2002
Database(s): PubMed (PMID/11803441)
DOI: 10.1038/sj/mp/4000950.
Link(s): http://www.nature.com/mp/journal/v7/n1/pdf/4000950a.pdf
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No association between dopamine D4 receptor gene variants and novelty seeking reports a personality genetics study on DRD4 C-521T genetic polymorphism and personality traits assessed with several different personality inventories: Temperament and Character Inventory, Karolinska Scales of Personality, Swedish Universities Scales of Personalities and Revised NEO Personality Inventory.

[edit] Subjects

Subject group #1 (help)
Healthy Swedes
Subjects/♂/♀: 381 / 211 / 170
Age: 42.5 ±13.4 (19–83)
Nationality: Swedish
Approval: Ethics Committee of the Karolinska Hospital
Databases:

Group 1 of 381 healthy Swedes with 211 males and 170 females were included in the study. The Swedish group had a mean age of 42.5 with a range from 19 to 83. The study on the human subjects was approved by the Ethics Committee of the Karolinska Hospital.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 C-521T C/C TCI Novelty seeking 23.0 4.8 44 Healthy Swedes 11803441
DRD4 C-521T C/C TCI Exploratory excitability 7.5 2.0 44 Healthy Swedes 11803441
DRD4 C-521T C/C TCI Impulsiveness 5.4 2.4 44 Healthy Swedes 11803441
DRD4 C-521T C/C TCI Extravagance 5.6 1.9 44 Healthy Swedes 11803441
DRD4 C-521T C/C TCI Disorderliness 4.4 1.7 44 Healthy Swedes 11803441
DRD4 C-521T C/T TCI Novelty seeking 21.7 5.8 167 Healthy Swedes 11803441
DRD4 C-521T C/T TCI Exploratory excitability 7.4 2.2 167 Healthy Swedes 11803441
DRD4 C-521T C/T TCI Impulsiveness 4.7 2.4 167 Healthy Swedes 11803441
DRD4 C-521T C/T TCI Extravagance 5.5 1.9 167 Healthy Swedes 11803441
DRD4 C-521T C/T TCI Disorderliness 4.1 1.9 167 Healthy Swedes 11803441
DRD4 C-521T T/T TCI Novelty seeking 21.0 5.9 98 Healthy Swedes 11803441
DRD4 C-521T T/T TCI Exploratory excitability 7.0 2.5 98 Healthy Swedes 11803441
DRD4 C-521T T/T TCI Impulsiveness 4.8 2.2 98 Healthy Swedes 11803441
DRD4 C-521T T/T TCI Extravagance 5.2 2.0 98 Healthy Swedes 11803441
DRD4 C-521T T/T TCI Disorderliness 4.0 1.9 98 Healthy Swedes 11803441
DRD4 C-521T C/C KSP Impulsiveness 50.9 10.5 58 Healthy Swedes 11803441
DRD4 C-521T C/C KSP Monotony avoidance 53.4 7.6 58 Healthy Swedes 11803441
DRD4 C-521T C/T KSP Impulsiveness 52.0 9.3 198 Healthy Swedes 11803441
DRD4 C-521T C/T KSP Monotony avoidance 53.5 10.7 198 Healthy Swedes 11803441
DRD4 C-521T T/T KSP Impulsiveness 50.5 9.9 112 Healthy Swedes 11803441
DRD4 C-521T T/T KSP Monotony avoidance 53.1 10.4 112 Healthy Swedes 11803441
DRD4 C-521T C/C SSP Impulsiveness 49.7 9.2 58 Healthy Swedes 11803441
DRD4 C-521T C/C SSP Adventure seeking 50.7 7.3 58 Healthy Swedes 11803441
DRD4 C-521T C/T SSP Impulsiveness 51.4 8.7 196 Healthy Swedes 11803441
DRD4 C-521T C/T SSP Adventure seeking 50.4 9.3 196 Healthy Swedes 11803441
DRD4 C-521T T/T SSP Impulsiveness 50.4 9.2 111 Healthy Swedes 11803441
DRD4 C-521T T/T SSP Adventure seeking 49.6 9.2 111 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Extraversion 115.1 19.0 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Warmth 21.8 4.7 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Gregariousness 20.2 4.8 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Excitement seeking 16.9 4.9 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Positive emotions 22.1 3.8 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Impulsiveness 15.9 5.2 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Modesty 20.7 3.7 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Conscientiousness 116.0 19.0 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Order 17.4 4.0 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Dutifulness 23.6 3.5 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Deliberation 16.8 4.6 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Openness to experience 119.1 14.6 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Feelings 21.3 3.7 18 Healthy Swedes 11803441
DRD4 C-521T C/C NEO PI-R Action 18.8 3.5 18 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Extraversion 115.7 19.4 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Warmth 22.7 4.1 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Gregariousness 20.2 4.7 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Excitement seeking 15.6 4.8 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Positive emotions 21.6 6.2 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Impulsiveness 14.4 4.4 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Modesty 19.8 4.8 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Conscientiousness 122.4 18.3 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Order 18.8 3.8 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Dutifulness 24.7 3.9 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Deliberation 18.5 4.7 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Openness to experience 113.5 22.0 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Feelings 20.7 4.4 78 Healthy Swedes 11803441
DRD4 C-521T C/T NEO PI-R Action 18.1 4.9 78 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Extraversion 110.7 18.4 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Warmth 21.1 4.3 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Gregariousness 19.5 4.4 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Excitement seeking 15.5 4.8 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Positive emotions 20.6 5.5 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Impulsiveness 15.3 3.7 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Modesty 19.8 4.9 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Conscientiousness 120.9 18.9 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Order 18.6 4.5 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Dutifulness 24.7 3.7 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Deliberation 17.9 4.2 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Openness to experience 114.3 22.0 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Feelings 22.0 4.7 44 Healthy Swedes 11803441
DRD4 C-521T T/T NEO PI-R Action 16.5 4.3 44 Healthy Swedes 11803441

[edit] Critique

  1. The study cannot conclude that C-521T is not related to novelty seeking: The effect size is in the same direction of the Okuyama study, - it is just not significant.
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