Hippocampal volume reduction in major depression

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Paper (help)
Hippocampal volume reduction in major depression
Authors: J. Douglas Bremner, Meena Narayan, Eric R. Anderson, Lawrence H. Staib, Helen L. Miller, Dennis S. Charney
Citation: American Journal of Psychiatry 157 (1): 115-117. 2000 January
Database(s): PubMed (PMID/10618023)
DOI: Define doi.
Link(s): http://ajp.psychiatryonline.org/cgi/reprint/157/1/115
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Hippocampal volume reduction in major depression reports a magnetic resonance imaging study on patients with major depression with results on volumes of hippocampus, caudate, amygdala, frontal lobe and temporal lobe. Against comparison subject the patients showed some difference: Smaller hippocampus and larger amygdala.

Two earlier studies of hippocampal volume in major depression is mentioned in the paper: Hypercortisolemia and hippocampal changes in depression and Hippocampal atrophy in recurrent major depression (there is a typo in the bibliography for the title of the latter paper).

There is a comment on the paper by Van Elst and Trimble.[1]

[edit] Subjects

Subject group #1 (help)
Major depression patients
Subjects/♂/♀: 16 / 10 / 6
Age: 43 ±8 (–)
Nationality: American
Approval: define approval
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Group 1 of 16 major depression patients with 10 males and 6 females were included in the study.

The American group had a mean age of 43.
Subject group #2 (help)
Comparison subjects
Subjects/♂/♀: 16 / 10 / 6
Age: 45 ±10 (–)
Nationality: American
Approval: define approval
Databases:

Group 2 of 16 comparison subjects with 10 males and 6 females were included in the study. The American group had a mean age of 45.

The comparison subjects were matched for sex and handedness.

[edit] Results

Table 1 with 32 volume results. Both left, right and mean values for volumes are given for each 5 regions investigated.

There is only one value given for the "whole brain" region.
#
Mean
Std
SEM
Unit
Anatomy
Group
No. (M/F)
Age
1 0.940 0.208 cm3 Left hippocampus Major depression patients (/) (–)
2 1.166 0.248 cm3 Left hippocampus Comparison subjects (/) (–)
3 0.982 0.269 cm3 Right hippocampus Major depression patients (/) (–)
4 1.113 0.194 cm3 Right hippocampus Comparison subjects (/) (–)
31 1404.586 179.994 cm3 Brain Major depression patients (/) (–)
32 1390.789 153.948 cm3 Brain Comparison subjects (/) (–)
Entry not completed (help)

[edit] References

  1. L. T. Van Elst, M. R. Trimble (2001). "Hippocampus and amygdala pathology in depression". American Journal of Psychiatry 158(4): 652-653. PMID: 11282710.
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