Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women

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Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women
Authors: Jonas Melke, M. Landen, F. Baghei, R. Rosmond, G. Holm, P. Bjorntorp, L. Westberg, M. Hellstrand, Elias Eriksson
Citation: American journal of medical genetics 105 (5): 458-453. 2001 July
Database(s): PubMed (PMID/11449399)
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Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women reports a personality genetics study on the 5-HTTLPR and STin2 genetic polymorphisms around and in the SLC6A4 and personality traits assessed with the Karolinska Scales of Personality.

[edit] Subject

Subject group #1 (help)
Swedish women
Subjects/♂/♀: 251 / 0 / 251
Age: (–)
Nationality: Swedish
Approval: Ethical committee of Göteborg University
Databases:

Group 1 of 251 swedish women with 0 males and 251 females were included in the study.

The study on the human subjects was approved by the Ethical committee of Göteborg University. The women was all born in 1956.

8 subjects with STin2.9 allele were excluded.

251 women where assesed with KSP and genotyped (page 459). In Table 1 only 187-193 subjects are reported. 60 were excluded since they were not homozygote for a least one of the 5-HTTLPR or STin2.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR short/short KSP Somatic anxiety 49.4 9.4 34 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR short/short KSP Psychic anxiety 48.3 10.5 34 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR short/short KSP Muscular tension 52.9 11.5 34 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR short/short KSP Psychasthenia 51.5 13.2 34 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR short/short KSP Lack of assertiveness 51.5 9.4 34 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/short KSP Somatic anxiety 47.3 11.0 83 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/short KSP Psychic anxiety 43.1 10.6 83 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/short KSP Muscular tension 48.9 9.6 83 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/short KSP Psychasthenia 45.4 11.3 83 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/short KSP Lack of assertiveness 45.8 8.4 83 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/long KSP Somatic anxiety 47.0 8.9 70 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/long KSP Psychic anxiety 44.5 10.2 70 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/long KSP Muscular tension 49.6 9.0 70 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/long KSP Psychasthenia 46.9 11.0 70 Caucasian Swedish women 11449399
SLC6A4 5-HTTLPR long/long KSP Lack of assertiveness 47.6 8.3 70 Caucasian Swedish women 11449399
SLC6A4 STin2 10/10 KSP Somatic anxiety 44.6 8.6 35 Caucasian Swedish women 11449399
SLC6A4 STin2 10/10 KSP Psychic anxiety 42.5 9.7 35 Caucasian Swedish women 11449399
SLC6A4 STin2 10/10 KSP Muscular tension 47.4 8.4 35 Caucasian Swedish women 11449399
SLC6A4 STin2 10/10 KSP Psychasthenia 45.3 9.5 35 Caucasian Swedish women 11449399
SLC6A4 STin2 10/10 KSP Lack of assertiveness 45.9 8.3 35 Caucasian Swedish women 11449399
SLC6A4 STin2 10/12 KSP Somatic anxiety 46.8 9.4 84 Caucasian Swedish women 11449399
SLC6A4 STin2 10/12 KSP Psychic anxiety 44.1 10.5 84 Caucasian Swedish women 11449399
SLC6A4 STin2 10/12 KSP Muscular tension 49.4 9.6 84 Caucasian Swedish women 11449399
SLC6A4 STin2 10/12 KSP Psychasthenia 46.7 11.9 84 Caucasian Swedish women 11449399
SLC6A4 STin2 10/12 KSP Lack of assertiveness 48.7 8.8 84 Caucasian Swedish women 11449399
SLC6A4 STin2 12/12 KSP Somatic anxiety 49.9 10.9 60 Caucasian Swedish women 11449399
SLC6A4 STin2 12/12 KSP Psychic anxiety 46.3 10.7 60 Caucasian Swedish women 11449399
SLC6A4 STin2 12/12 KSP Muscular tension 51.7 11.0 60 Caucasian Swedish women 11449399
SLC6A4 STin2 12/12 KSP Psychasthenia 48.5 12.4 60 Caucasian Swedish women 11449399
SLC6A4 STin2 12/12 KSP Lack of assertiveness 47.2 8.4 60 Caucasian Swedish women 11449399
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