No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking

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No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking
Authors: A. Strobel, Klaus-Peter Lesch, K. Hohenberger, S. Jatzke, H. O. Gutzeit, K. Anacker, B. Brocke
Citation: Molecular psychiatry 7 (6): 537-538. 2002
Database(s): PubMed (PMID/12140774)
DOI: 10.1038/sj.mp.4001027.
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Extract:

No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking reports a personality genetics study on DRD4 exon 3 VNTR and C-521T genetic polymorphisms together with the personality trait novelty seeking from the Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Healthy Germans
Subjects/♂/♀: 276 / 71 / 205
Age: 21.9 ±3.9 (18–41)
Nationality: German
Approval: define approval
Databases:

Group 1 of 276 healthy Germans with 71 males and 205 females were included in the study. The German group had a mean age of 21.9 with a range from 18 to 41.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 Exon 3 VNTR -7/-7 TCI Novelty seeking 17.20 5.43 183 Healthy Germans 12140774
DRD4 Exon 3 VNTR 7 TCI Novelty seeking 17.97 5.21 93 Healthy Germans 12140774
DRD4 Exon 3 VNTR 2/4 TCI Novelty seeking 15.44 5.63 32 Healthy Germans 12140774
DRD4 Exon 3 VNTR 4/4 TCI Novelty seeking 17.73 5.50 120 Healthy Germans 12140774
DRD4 Exon 3 VNTR 4/7 TCI Novelty seeking 17.66 5.37 71 Healthy Germans 12140774
DRD4 C-521T C/C TCI Novelty seeking 17.38 5.42 69 Healthy Germans 12140774
DRD4 C-521T C/T TCI Novelty seeking 17.28 5.27 137 Healthy Germans 12140774
DRD4 C-521T T/T TCI Novelty seeking 17.89 5.53 70 Healthy Germans 12140774
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