Interaction between BDNF val66met and dopamine transporter gene variation influences anxiety-related traits

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Paper (help)
Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits
Authors: Regina Hünnerkopf, Alexander Strobel, Lise Gutknecht, Burkhard Brocke, Klaus-Peter Lesch
Citation: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 32 (12): 2552-2560. 2007 December
Database(s): PubMed (PMID/17392738)
DOI: 10.1038/sj.npp.1301383.
Link(s): http://www.nature.com/npp/journal/v32/n12/pdf/1301383a.pdf
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Interaction between BDNF val66met and dopamine transporter gene variation influences anxiety-related traits reports a personality genetics study on the rs6265 (val66met) genetic polymorphism in the BDNF gene with personality traits assessed with NEO PI-R and Tridimensional Personality Questionnaire.

[edit] Subjects

Subject group #1 (help)
Healthy German university staff and students
Subjects/♂/♀: 272 /  / 201
Age: 21.9 ±3.8 (18–41)
Nationality: German
Approval: define approval
Databases:

Group 1 of 272 healthy German university staff and students were included in the study. The German group had a mean age of 21.9 with a range from 18 to 41.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
BDNF met66val met/met NEO PI-R Neuroticism 93.2 18.3 9 Healthy German university staff and students 17392738
BDNF met66val met/met NEO PI-R Anxiety 15.9 5.4 9 Healthy German university staff and students 17392738
BDNF met66val met/met NEO PI-R Angry hostility 13.3 3.9 9 Healthy German university staff and students 17392738
BDNF met66val met/met NEO PI-R Depression 14.7 5.1 9 Healthy German university staff and students 17392738
BDNF met66val met/met NEO PI-R Self-consciousness 16.7 5.4 9 Healthy German university staff and students 17392738
BDNF met66val met/met NEO PI-R Impulsiveness 19.6 3.9 9 Healthy German university staff and students 17392738
BDNF met66val met/met NEO PI-R Vulnerability 13.1 4.8 9 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Neuroticism 95.6 24.09 74 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Anxiety 17.4 6.02 74 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Angry hostility 13.3 5.16 74 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Depression 15.2 6.02 74 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Self-consciousness 18.4 5.16 74 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Impulsiveness 18.2 5.16 74 Healthy German university staff and students 17392738
BDNF met66val met/val NEO PI-R Vulnerability 13.1 5.16 74 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Neuroticism 95.5 26.12 189 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Anxiety 17.2 6.87 189 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Angry hostility 14.3 5.5 189 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Depression 15.5 6.87 189 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Self-consciousness 17.5 5.5 189 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Impulsiveness 17.9 4.12 189 Healthy German university staff and students 17392738
BDNF met66val val/val NEO PI-R Vulnerability 13.1 5.5 189 Healthy German university staff and students 17392738

[edit] Critique

  1. Biased reporting: The harm avoidance trait was analyzed but only F-statistics and no personality scores across genotypes were reported.
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