Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety

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Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
Authors: Justine M. Gatt, C. B. Nemeroff, Carol Dobson-Stone, R. H. Paul, R. A. Bryant, P. R. Schofield, E. Gordon, Andrew H. Kemp, L. M. Williams
Citation: Molecular psychiatry 14 (7): 681-685. 2009 July
Database(s): PubMed (PMID/19153574)
DOI: 10.1038/mp.2008.143.
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Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety reports a personality genetics study on the val66met genetic polymorphism in the BDNF gene.

There are supplementary material for the paper: [1].

[edit] Subjects

Subject group #1 (help)
Healthy Caucasian Australians
Subjects/♂/♀: 374 /  / 190
Age: 36.2 ±12.7 (–)
Nationality: Australian
Approval: define approval
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Group 1 of 374 healthy Caucasian Australians were included in the study. The Australian group had a mean age of 36.2.

The subjects participated in the collaboration with the Brain Resource International Database.

[edit] Results

Raw personality scores across genotypes are available in the Supplementary Table 5 for neuroticism.
Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
BDNF met66val val/val DASS21 Depression 4.34 5.94 242 Healthy Caucasian Australians 19153574
BDNF met66val met DASS21 Depression 3.97 4.88 132 Healthy Caucasian Australians 19153574
BDNF met66val val/val DASS21 Anxiety 2.14 3.31 242 Healthy Caucasian Australians 19153574
BDNF met66val met DASS21 Anxiety 1.95 2.94 132 Healthy Caucasian Australians 19153574
BDNF met66val val/val NEO-FFI Neuroticism 19.02 7.37 242 Healthy Caucasian Australians 19153574
BDNF met66val met NEO-FFI Neuroticism 18.19 7.40 132 Healthy Caucasian Australians 19153574
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