Variants of the serotonin transporter gene and NEO-PI-R neuroticism: no association in the BLSA and SardiNIA samples

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Variants of the serotonin transporter gene and NEO-PI-R neuroticism: no association in the BLSA and SardiNIA samples
Authors: Antonio Terracciano, Lenuta Balaci, Jason Thayer, Matthew Scally, Sarah Kokinos, Luigi Ferrucci, Toshiko Tanaka, Alan B Zonderman, Serena Sanna, Nazario Olla, Maria Antonietta Zuncheddu, Silvia Naitza, Fabio Busonero, Manuela Uda, David Schlessinger, Gonçalo R. Abecasis, Paul T. Costa, Jr.
Citation: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (8): 1070-1077. 2009 December
Database(s): PubMed (PMID/19199283)
DOI: 10.1002/ajmg.b.30932.
PMCID:2788669
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Variants of the serotonin transporter gene and NEO-PI-R neuroticism: no association in the BLSA and SardiNIA samples reports a large personality genetics study on the 5-HTTLPR polymorphism and NEO PI-R neuroticism personality trait.


[edit] Subjects

Subject group #1 (help)
SardiNIA
Description: Sardinians from the Lanusei Valley
Subjects/♂/♀: 3913 /  /
Age: (14–102)
Nationality: Italian
Approval: Institutional review boards in Italy and USA
Databases:

Group 1 of 3913 sardiNIA were included in the study. The Italian group was from 14 up to 102 years old. The study on the human subjects was approved by the Institutional review boards in Italy and USA.

Details on the demographics fro the SardiNIA are available in Personality traits in Sardinia: testing founder population effects on trait means and variances and Heritability of cardiovascular and personality traits in 6,148 Sardinians.
Subject group #2 (help)
BLSA
Description: Community-dwelling volunteers from Baltimore Longitudinal Study of Aging
Subjects/♂/♀: 548 /  /
Age: (20–87)
Nationality: American
Approval: Local institutional review board
Databases:

Group 2 of 548 bLSA were included in the study. The American group was from 20 up to 87 years old. The study on the human subjects was approved by the Local institutional review board. In BLSA 51% were women. The population overlaps with a Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 56.5 8.71 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 56.4 8.76 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 56.4 8.65 1026 Sardinians 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Anxiety 57.0 8.4 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Anxiety 56.8 8.33 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Anxiety 57.4 8.65 1026 Sardinians 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Angry Hostility 54.1 9.33 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Angry Hostility 53.9 9.2 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Angry Hostility 53.6 9.29 1026 Sardinians 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Depression 54.8 9.33 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Depression 54.8 9.2 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Depression 55.0 9.29 1026 Sardinians 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Self-consciousness 52.7 9.95 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Self-consciousness 52.5 9.64 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Self-consciousness 52.2 9.93 1026 Sardinians 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Impulsiveness 47.8 8.71 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Impulsiveness 48.0 8.76 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Impulsiveness 48.0 8.65 1026 Sardinians 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Vulnerability 57.1 10.26 967 Sardinians 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Vulnerability 57.2 10.08 1920 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Vulnerability 57.7 10.25 1026 Sardinians 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Neuroticism 48.4 8.71 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Neuroticism 46.3 8.64 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Neuroticism 47.5 8.64 101 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Anxiety 49.1 8.57 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Anxiety 46.5 8.64 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Anxiety 48.2 8.64 101 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Angry Hostility 48.2 8.57 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Angry Hostility 47.7 8.48 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Angry Hostility 48.6 8.54 101 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Depression 48.2 8.43 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Depression 46.1 8.48 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Depression 47.9 8.44 101 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Self-consciousness 49.2 8.71 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Self-consciousness 47.7 8.8 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Self-consciousness 48.1 8.74 101 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Impulsiveness 49.7 8.15 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Impulsiveness 48.4 8.16 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Impulsiveness 50.8 8.14 101 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/long NEO PI-R Vulnerability 48.7 8.15 191 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR long/short NEO PI-R Vulnerability 46.8 8.16 256 American community-dwelling volunteers 19199283
SLC6A4 5-HTTLPR short/short NEO PI-R Vulnerability 47.5 8.14 101 American community-dwelling volunteers 19199283
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