Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder

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Paper (help)
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Authors: Diego A. Pizzagalli, Avram J. Holmes, Daniel G. Dillon, Elena L. Goetz, Jeffrey L. Birk, Ryan Bogdan, Darin D. Dougherty, Dan V. Iosifescu, Scott L. Rauch, Maurizio Fava
Citation: The American journal of psychiatry 166 (6): 702-710. 2009 June
Database(s): PubMed (PMID/19411368)
DOI: 10.1176/appi.ajp.2008.08081201.
Link(s): http://anglab.com/PDF/Pizzagalli_AJP09.pdf
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Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder is a study with functional and structural magnetic resonance imaging on a group of patients with major depressive disorder and control subjects.

[edit] Subjects

Subject group #1 (help)
Comparison group
Subjects/♂/♀: 31 /  / 13
Age: 38.80 ±14.48 (–)
Nationality: define nationality
Approval: Committee on the Use of Human Subjects in Research at Harvard University and the Partners Human Research Committee
Databases:

Group 1 of 31 comparison group were included in the study. The group had a mean age of 38.80.

The study on the human subjects was approved by the Committee on the Use of Human Subjects in Research at Harvard University and the Partners Human Research Committee.
Subject group #2 (help)
Major depression group
Subjects/♂/♀: 30 /  / 15
Age: 43.17 ±12.98 (–)
Nationality: define nationality
Approval: Committee on the Use of Human Subjects in Research at Harvard University and the Partners Human Research Committee.
Databases:

Group 2 of 30 major depression group were included in the study. The group had a mean age of 43.17. The study on the human subjects was approved by the Committee on the Use of Human Subjects in Research at Harvard University and the Partners Human Research Committee..

[edit] Scanning

MRI Scanning (help)
Mode: aMRI
Scanner: Siemens Medical Systems Symphony/Sonata 1.5T
Type: MPRAGE

(TR=2730ms, TE=3.39ms, FA=?)

Slices: 128
Size: FOV=256mm resolution=1 x 1 x 1.33mm
Laboratory: missing laboratory

For aMRI MPRAGE scans were acquired with a 1.5T Siemens Medical Systems Symphony/Sonata.

MRI Scanning (help)
Mode: aMRI
Scanner: Siemens Medical Systems Symphony/Sonata 1.5T
Type: Echo-planar

(TR=2500ms, TE=35ms, FA=?)

Slices: 35 aquired Interleaved
Size: FOV=200mm resolution=3.125 x 3.125 x 3mm
Laboratory: missing laboratory

For aMRI Echo-planar scans were acquired with a 1.5T Siemens Medical Systems Symphony/Sonata.

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