Personality genetics

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Personality genetics
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Personality genetics is a branch of behavioral genetics examining the association between the genome (typically just a single genetic variant) and personality (typically quantified with personality questionnaires such as NEO PI-R).

Research has been focused on genetic variants in the serotonin system and the dopamine system.

Contents

[edit] Papers

In the Brede Wiki personality genetics papers with data are listed in the Gene personality associations category.

[edit] Meta-analysis

  1. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data
  2. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety
  3. An update on molecular genetic studies of human personality traits
  4. Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data
  5. BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
  6. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? a meta-analysis
  7. DRD4 and novelty seeking: results of meta-analyses
  8. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis
  9. Genetic variants implicated in personality: a review of the more promising candidates
  10. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety related personality traits

[edit] Genome-wide

  1. Meta-analysis of genome-wide association studies for personality

[edit] Original research

  1. 5-HT1A polymorphism and self-transcendence in mood disorders
  2. 5-HT2A SNPs and the Temperament and Character Inventory
  3. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms
  4. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data
  5. A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression
  6. A dinucleotide repeat polymorphism at the gene for monoamine oxidase A and measures og aggressiveness
  7. A gene–environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
  8. A genetic association for cigarette smoking behavior
  9. A polymorphic region in the human transcription factor AP-2beta gene is associated with specific personality traits
  10. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women
  11. A possible association between the val158met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects
  12. A regulatory monoamine oxidase A promoter polymorphism and personality traits
  13. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
  14. A tryptophan hydroxylase gene marker for suicidality and alcoholism
  15. Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking
  16. Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: replication tests
  17. Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits
  18. Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits
  19. An association between dopamine D4 receptor and transporter gene polymorphisms and personality traits, assessed using NEO-FFI in a Polish female population
  20. An association of GRIK3 Ser310Ala functional polymorphism with personality traits
  21. An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms
  22. An association study of catechol-O-methyltransferase and monoamine oxidase A polymorphisms and personality traits in Koreans
  23. An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients
  24. An association study of the 5-HTTLPR and COMT genes polymorphisms and personality traits
  25. An examination of the association between DRD4 and DRD2 polymorphisms and personality traits
  26. An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimensional personality questionnaire persistence scores in normal subjects
  27. An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females
  28. Androgen receptor trinucleotide repeat polymorphism and personality traits
  29. Anger- and aggression-related traits are associated with polymorphisms in the 5-HTT-2A gene
  30. Anxiety and comorbid measures associated with PLXNA2
  31. Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms
  32. Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese
  33. Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits
  34. Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women
  35. Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders
  36. Association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and novelty seeking personality in healthy females
  37. Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects
  38. Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese
  39. Association between dopamine D4 receptor (DRD4) exon III polymorphism and neuroticism in the Japanese population
  40. Association between GSK-3beta -50T/C polymorphism and personality and psychotic symptoms in mood disorders
  41. Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals
  42. Association between monoamine oxidase A polymorphisms and anger-related personality traits in Korean women
  43. Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects
  44. Association between novelty seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene
  45. Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample
  46. Association between novelty seeking of opiate-dependent patients and the catechol-O-methyltransferase val158met polymorphism
  47. Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics
  48. Association between serotonin transporter gene polymorphism and anxiety-related traits
  49. Associations between the COMT Val/Met polymorphism, early life stress, and personality among healthy adults
  50. Association between the estrogen receptor TA polymorphism and harm avoidance
  51. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample
  52. Association between the type 4 dopamine receptor gene polymorphism and novelty seeking
  53. Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT)
  54. Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits
  55. Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population
  56. Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population
  57. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
  58. Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysenck's P and other personality traits
  59. Association of DRD4 and COMT polymorphisms with anger and forgiveness traits in healthy volunteers
  60. Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey
  61. Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects
  62. Association of the functional catechol-O-methyltransferase val158met polymorphism with the personality trait of extraversion
  63. Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population
  64. Association study between a functional polymorphism of tyrosine hydroxylase gene promoter and personality traits in healthy subjects
  65. Association study between dopamine D3 receptor gene variant and personality traits
  66. Association study between reward dependence temperament and a polymorphism in the phenylethanolamine N-methyltransferase gene in a Japanese female population
  67. Association study between the -1021C/T polymorphism of the dopamine-beta-hydroxylase gene promoter and personality traits in healthy subjects
  68. Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders
  69. Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females
  70. Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females
  71. Association study of a functional MAOA-uVNTR gene polymorphism and personality traits in Chinese young females
  72. Association study of catechol-O-methyltransferase val158met polymorphism with personality traits in Japanese healthy volunteers
  73. Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females
  74. Association study of the cytochrome P450 17 gene polymorphism with personality traits in healthy subjects
  75. Association study between the -1021C/T polymorphism of the dopamine-beta-hydroxylase gene promoter and personality traits in healthy subjects.
  76. Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender
  77. BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism
  78. BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects
  79. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex
  80. Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females
  81. Combined analysis of association between personality traits and three functional polymorphisms in the tyrosine hydroxylase, monoamine oxidase A, and catechol-O-methyltransferase genes
  82. COMT and DRD3 polymorphisms, environmental exposures, and personality traits related to common mental disorders
  83. COMT polymorphisms and anxiety-related personality traits
  84. Correlation analyses of ALDH2 and CYP2E1 genetic polymorphism with personality
  85. CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms
  86. CYP2C19 polymorphism affects personality traits of Japanese females
  87. D2 and D4 dopamine receptor polymorphisms and personality
  88. D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population
  89. D2 dopamine receptor (DRD2) gene, P300, and personality in children of alcoholics
  90. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects
  91. Do the dimensions of the temperament and character inventory map a simple genetic architecture? evidence from molecular genetics and factor analysis
  92. Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects?
  93. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking
  94. Dopamine D 4 receptor gene polymorphism and extraversion revisited: results from the Munich gene bank project for alcoholism
  95. Dopamine system genes and personality traits of extraversion and novelty seeking
  96. DRD4 and DAT1 as modifying genes in alcoholism: interaction with novelty seeking on level of alcohol consumption
  97. DRD4 promoter SNPs and gender effects on Extraversion in African Americans
  98. Effects of HTR1A C (-1019) G on amygdala reactivity and trait anxiety
  99. Effect of COMT val158met genotype on cognition and personality
  100. Effect of the cytochrome P450 19 (aromatase) gene polymorphism on personality traits in healthy subjects
  101. Follow-up association study of novel neuroticism gene MAMDC1
  102. Functional polymorphism of the glutathione peroxidase 1 gene is associated with personality traits in healthy subjects
  103. Further evidence for a modulation of novelty seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants
  104. Gender-dependent association of a functional NGF polymorphism with anxiety-related personality traits
  105. Gender-dependent association of the functional catechol-O-methyltransferase Val158Met genotype with sensation seeking personality trait
  106. Gender differences in association between serotonin transporter gene polymorphism and personality traits
  107. Genes encoding for AP-2β and the serotonin transporter are associated with the personality character spiritual acceptance
  108. Genetic association analysis of behavioral inhibition using candidate loci from mouse models
  109. Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa
  110. Hypnotic susceptibility: multidimensional relationships with Cloninger's Tridimensional Personality Questionnaire, COMT polymorphisms, absorption, and attentional characteristics
  111. Identification of a polymorphism in the promoter region of the DRD4 associated with the human novelty seeking personality trait
  112. Influence of androgen receptor repeat polymorphisms on personality traits in men
  113. Insertion-deletion polymorphism of the serotonin carrier gene and evaluation of neurotism as a temperament trait in patients with affective disorders and mentally healthy people (In Russian)
  114. Interaction between BDNF val66met and dopamine transporter gene variation influences anxiety-related traits
  115. Interaction between brain-derived neurotrophic factor val66met polymorphism and recent negative stressor in harm avoidance
  116. Interaction between serotonin 5-HT2A receptor gene and dopamine transporter (DAT1) gene polymorphisms influences personality trait of persistence in Austrian Caucasians
  117. Interactions between BDNF val66met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
  118. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking
  119. Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior
  120. Lack of association between a polymorphism in the promoter region of the dopamine D2 receptor and personality traits
  121. Lack of association between dopamine D4 receptor gene and personality traits
  122. Lack of association between polymorphisms of the dopamine D4 receptor gene and personality
  123. Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population
  124. Lack of association of a single-nucleotide polymorphism of the μ-opioid receptor gene with anxiety-related traits: results from a cross-sectional study of adults and a longitudinal study of children
  125. Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms
  126. Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals
  127. MAOA-uVNTR polymorphism in a Brazilian sample: further support for the association with impulsive behaviors and alcohol dependence
  128. Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects
  129. Monoamine oxidase A gene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants
  130. Nature and nurture in suicidal behavior, the role of genetics: some novel findings concerning personality traits and neural conduction
  131. Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans
  132. Neuroendocrine support for a relationship between 'novelty seeking' and dopaminergic function in alcohol-dependent men
  133. Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism
  134. No association between 5-HTTLPR and harm avoidance in Korean college students
  135. No association between CYP2D6 polymorphisms and personality trait in Japanese
  136. No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking
  137. No association between dopamine D4 receptor gene variants and novelty seeking
  138. No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females
  139. No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects
  140. No association between the -3081A/T polymorphism in the norepinephrine transporter gene promoter and personality traits in healthy subjects
  141. No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits
  142. No association between the CNTF null mutation and schizophrenia or personality
  143. No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples
  144. No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects
  145. No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance
  146. No association between the TPH A218C polymorphism and personality traits in Japanese healthy subjects
  147. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population
  148. No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits
  149. No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism
  150. No association of DRD2, DRD3, and tyrosine hydroxylase gene polymorphisms with personality traits in the Japanese population
  151. No association of the -521 C/T polymorphism in the promoter of DRD4 with novelty seeking
  152. No evidence for an association between the BDNF val66met polymorphism and schizophrenia or personality traits
  153. No significant associations between two dopamine receptor polymorphisms and normal temperament
  154. Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals
  155. Norepinephrine transporter and alpha2c adrenoceptor allelic variants and personality factors
  156. Norepinephrine transporter polymorphism and personality trait of reward dependence in male alcoholics
  157. Personality and the serotonin transporter gene: Associations in a longitudinal population-based study
  158. Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students
  159. Personality traits and DRD4, DAT1, 5-HT2A gene polymorphisms in risky and non risky sports participation
  160. Personality traits in young female apolipoprotein E (apoE) e4 and non-e4 carriers
  161. Phenotypic and genotypic characteristics of women in relation to personality traits
  162. Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population
  163. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers
  164. Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers
  165. Polymorphisms in the serotonin transporter gene and their relationship to two temperamental traits measured by the formal characteristics of behavior-temperament inventory: activity and emotional reactivity
  166. Polymorphisms of the serotonin transporter gene (5-HTTLPR, A/G SNP in 5-HTTLPR, and STin2 VNTR) and their relation to personality traits in healthy individuals from Russia
  167. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking
  168. Potential role of the estrogen receptor gene (ESR1) in anxiety
  169. Relation between CYP2D6 genotype, personality, neurocognition and overall psychopathology in healthy volunteers
  170. Relation between CYP2D6 phenotype and genotype and personality in healthy volunteers
  171. Relationship between neuroticism personality trait and serotonin transporter binding
  172. Relationship between personality and debrisoquine hydroxylation capacity. suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
  173. Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
  174. Relationships between angry-impulsive personality traits and genetic polymorphisms of the dopamine transporter
  175. Role of dopamine transporter gene (DAT1) polymorphisms in personality traits variation
  176. Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population
  177. Role of the serotonin transporter promoter polymorphism in anxiety-related traits (5-HTTLPR, TPQ)
  178. Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder
  179. Serotonin 5-HT2A receptor gene polymorphism, 5-HT2A receptor function and personality traits in healthy subjects: a negative study
  180. Serotonin receptor 3A (HTR3A) gene is associated with personality traits, but not panic disorder
  181. Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls
  182. Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism
  183. Serotonin transporter gene polymorphism and personality traits measured by MMPI
  184. Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese
  185. Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese
  186. Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population
  187. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism
  188. Serotonergic genes and personality traits in the Korean population
  189. Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population
  190. Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorpisms
  191. Temperament and character profiles and the dopamine D4 receptor gene in ADHD
  192. The -181 A/C polymorphism in the excitatory amino acid transporter-2 gene promoter affects the personality trait of reward dependence in healthy subjects
  193. The -67 A/T promoter polymorphism in the dopamine transporter gene affects personality traits of Japanese healthy females
  194. The androgen receptor gene and psychological traits: are results consistent in Sweden and Australia?
  195. The association between the dopamine D(4) receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking
  196. The association between personality, pain threshold and a single nucleotide polymorphism (rs3813034) in the 3'-untranslated region of the serotonin transporter gene (SLC6A4)
  197. The association of 5-HTTLPR and DRD4 VNTR polymorphisms with affective temperamental traits in healthy volunteers
  198. The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients
  199. The dopamine D2 receptor gene TaqI A1 polymorphism and alcoholism in a Mexican population
  200. The DRD4 gene and the spiritual transcendence scale of the character temperament index
  201. The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology
  202. Transcription factor AP-2beta genotype associated with anxiety-related personality traits in women. a replication study
  203. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
  204. Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits
  205. Variants of the serotonin transporter gene and NEO-PI-R neuroticism: no association in the BLSA and SardiNIA samples
  206. Variation at the DRD4 promoter modulates extraversion in Caucasians
  207. XBP1 gene polymorphism (-116C/G) and personality

[edit] Genome-wide

  1. Genome-wide association scan for five major dimensions of personality
  2. Genome-wide association study of personality traits in bipolar patients
  3. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism
  4. A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality
  5. A whole genome association study of neuroticism using DNA pooling

[edit] Researchers

  1. Marcus R. Munafò
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