Pituitary volume in pediatric obsessive-compulsive disorder

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Paper (help)
Pituitary volume in pediatric obsessive-compulsive disorder
Authors: Frank P. MacMaster, Aileen Russell, Yousha Mirza, Matcheri S. Keshavan, S. Preeya Banerjee, Rashmi Bhandari, Courtney Boyd, Michelle Lynch, Michelle Rose, Jennifer Ivey, Gregory J. Moore, David R. Rosenberg
Citation: Biological psychiatry 59 (3): 252-257. 2006 February
Database(s): PubMed (PMID/16140279)
DOI: 10.1016/j.biopsych.2005.06.028.
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Extract:

Pituitary volume in pediatric obsessive-compulsive disorder is a structural neuroimaging study with obsessive-compulsive disorder patients and the pituitary volume.

[edit] Subjects

Subject group #1 (help)
Obsessive-compulsive disorder pediatric patients
Subjects/♂/♀: 31 / 10 / 21
Age: 12.79 ±2.64 (8–17)
Nationality: American
Approval: Wayne State University Human Investigation Committee
Databases:

Group 1 of 31 obsessive-compulsive disorder pediatric patients with 10 males and 21 females were included in the study. The American group had a mean age of 12.79 with a range from 8 to 17.

The study on the human subjects was approved by the Wayne State University Human Investigation Committee.
Subject group #2 (help)
Healthy comparison
Subjects/♂/♀: 31 / 10 / 21
Age: 12.89 ±2.66 (–)
Nationality: American
Approval: Wayne State University Human Investigation Committee
Databases:

Group 2 of 31 healthy comparison with 10 males and 21 females were included in the study. The American group had a mean age of 12.89. The study on the human subjects was approved by the Wayne State University Human Investigation Committee.

The subject group overlaps and builds from Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder.

[edit] Results

Numerical results are not given, but pituitary volume mean and standard error are shown in Figure 2 for males and females separately.

From the figure in the paper it is not completely certain that the error bars indicated are the standard errors (and not the standard deviations), but Frank P. MacMaster (personal communication to Finn Årup Nielsen) acknowledge the following values:

Male Control N = 10 Mean = 0.5420 SE = 0.06636 SD = 0.20986
Female Control N = 21 Mean = 0.6776 SE = 0.04074 SD = 0.18668

Male OCD N = 10 Mean = 0.4340 SE = 0.04118 SD = 0.13023
Female OCD N = 21 Mean = 0.6233 SE = 0.03921 SD = 0.17970

For the p-values from the F-tests in the paper "age, height, weight, and intracranial volume were used as covariates".

[edit] Related papers

  1. A brain magnetic resonance imaging study of pituitary gland morphology in anorexia nervosa and bulimia
  2. Pituitary abnormalities in eating disorders: further evidence from MRI studies
  3. Smaller pituitary volume in adult patients with obsessive-compulsive disorder
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