Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population

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Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population
Authors: Vera E. Golimbet, I. K. Gritsenko, M. V. Alfimova, Richard P. Ebstein
Citation: Russian Journal of Genetics 41 (7): 789-793. 2005 July
Database(s): PubMed (PMID/16152802)
DOI: 10.1007/s11177-005-0161-2.
Link(s): http://www.springerlink.com/content/h73j75637x670n24/?p=cb434a9644d3438a88786146181c8a9f&pi=11
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Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population is a personality genetics study on the C-521T, G-809A and C-616G genetic polymorphisms in the DRD4 gene with personality traits assessed with the Eysenck Personality Inventory and MMPI and Temperament and Character Inventory.

It is also published in Genetika as:

Vera E. Golimbet, I. K. Gritsenko, M. V. Alfimova, Richard P. Ebstein (2005). "Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population". Genetika 41(7): 966-962. PMID: 16152802.

[edit] Subjects

Subject group #1 (help)
Healthy Russians without psychotic relatives
Subjects/♂/♀: 131 / 56 /
Age: 32.2 ±12.9 (–)
Nationality: Russian
Approval: define approval
Databases:

Group 1 of 131 healthy Russians without psychotic relatives with 56 males were included in the study.

The Russian group had a mean age of 32.2.
Subject group #2 (help)
Healthy Russians with psychotic relatives
Subjects/♂/♀: 89 / 45 /
Age: 45.7 ±14.8 (–)
Nationality: Russian
Approval: define approval
Databases:

Group 2 of 89 healthy Russians with psychotic relatives with 45 males were included in the study. The Russian group had a mean age of 45.7.


[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
DRD4 C-521T C/C EPI Extraversion 11.7 4.1 28 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/T EPI Extraversion 10.9 3.7 69 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T T/T EPI Extraversion 11.9 3.8 33 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/C MMPI Hypomania 60.8 10.6 28 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/T MMPI Hypomania 59.1 11.7 69 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T T/T MMPI Hypomania 57.5 11.9 33 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/C MMPI Social introversion 49.3 12.4 28 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/T MMPI Social introversion 50.4 10.9 66 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T T/T MMPI Social introversion 49.8 12.6 33 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G G/G EPI Extraversion 11 4.2 46 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/G EPI Extraversion 11.6 3.4 56 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/A EPI Extraversion 11.4 3.8 28 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G G/G MMPI Hypomania 57.7 9.4 43 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/G MMPI Hypomania 60.1 12.7 55 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/A MMPI Hypomania 59 12 28 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G G/G MMPI Social introversion 50.4 11.3 43 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/G MMPI Social introversion 50.7 11.6 55 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/A MMPI Social introversion 48 12 28 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G G/G EPI Extraversion 11.3 3.6 30 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/G EPI Extraversion 11.1 3.9 61 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/C EPI Extraversion 11.7 4.1 32 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G G/G MMPI Hypomania 60.3 13.1 30 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/G MMPI Hypomania 59.6 11.1 64 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/C MMPI Hypomania 57.7 11.1 32 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G G/G MMPI Social introversion 48.4 11.1 30 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/G MMPI Social introversion 50.5 10.9 64 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/C MMPI Social introversion 50.9 13.6 32 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/C EPI Extraversion 9.6 4.7 14 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T C/T EPI Extraversion 9.4 3.5 32 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T T/T EPI Extraversion 9.9 4.2 28 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T C/C MMPI Hypomania 54.8 11.1 15 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T C/T MMPI Hypomania 52.9 9.4 33 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T T/T MMPI Hypomania 54.3 10.9 30 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T C/C MMPI Social introversion 51.5 9 15 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T C/T MMPI Social introversion 50.2 11.3 33 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T T/T MMPI Social introversion 52.6 12.5 30 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G G/G EPI Extraversion 9.1 4.3 28 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G A/G EPI Extraversion 9.7 3.5 35 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G A/A EPI Extraversion 10.6 4.5 11 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G G/G MMPI Hypomania 55.5 11.9 35 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G A/G MMPI Hypomania 53.4 11.8 37 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G A/A MMPI Hypomania 51.2 6.3 13 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G G/G MMPI Social introversion 48.8 10.8 29 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G A/G MMPI Social introversion 52.6 10.5 37 Healthy Russians with psychotic relatives 16152802
DRD4 A-809G A/A MMPI Social introversion 51.2 11.5 13 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G G/G EPI Extraversion 9.3 4.3 17 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G C/G EPI Extraversion 9.4 3.9 39 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G C/C EPI Extraversion 10.4 3.8 18 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G G/G MMPI Hypomania 50.6 8.1 17 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G C/G MMPI Hypomania 54.8 10.6 44 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G C/C MMPI Hypomania 55.2 11.6 18 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G G/G MMPI Social introversion 51.6 10.9 17 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G C/G MMPI Social introversion 50.4 10.6 44 Healthy Russians with psychotic relatives 16152802
DRD4 C-616G C/C MMPI Social introversion 51.9 11.6 18 Healthy Russians with psychotic relatives 16152802
DRD4 C-521T C/C TCI Novelty seeking 10.8 3.7 17 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T C/T TCI Novelty seeking 9.2 2.8 35 Healthy Russians without psychotic relatives 16152802
DRD4 C-521T T/T TCI Novelty seeking 9.9 4.9 17 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G G/G TCI Novelty seeking 9.1 3.3 25 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/G TCI Novelty seeking 10.3 4.2 33 Healthy Russians without psychotic relatives 16152802
DRD4 A-809G A/A TCI Novelty seeking 10 2.8 11 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G G/G TCI Novelty seeking 10.7 5.0 12 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/G TCI Novelty seeking 10.0 3.5 41 Healthy Russians without psychotic relatives 16152802
DRD4 C-616G C/C TCI Novelty seeking 8.1 3.1 32 Healthy Russians without psychotic relatives 16152802
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