Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers

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Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers
Authors: Jerzy Samochowiec, Filip Rybakowski, Piotr Czerski, Marzena Zakrzewska, Genowefa Stepien, Jystyna Pelka-Wysiecka, Jan Horodnicki, Janusz K. Rybakowski, Joanna Hauser
Citation: Neuropsychobiology 43 (4): 248-243. 2001
Database(s): PubMed (PMID/11340364)
DOI: Define doi.
Link(s): http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=nps43248
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Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers reports a personality genetics study on genetic polymorphisms in the dopamine transporter gene (SLC6A3, 40-bp VNTR), serotonin transporter gene (SLC6A4, 5-HTTLPR) and the norepinephrine transporter gene (SLC6A2, rs5569) with personality traits assessed with the Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Healthy Polish medical students
Subjects/♂/♀: 127 / 52 / 75
Age: 23.8 ±1.7 (–)
Nationality: Polish
Approval: Ethics Committees of the University Medical Sciences in Poznań and the Pomeranian Academy of Medicine in Szczecin
Databases:

Group 1 of 127 healthy Polish medical students with 52 males and 75 females were included in the study. The Polish group had a mean age of 23.8. The study on the human subjects was approved by the Ethics Committees of the University Medical Sciences in Poznań and the Pomeranian Academy of Medicine in Szczecin.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A3 40-bp VNTR 9/9 TCI Novelty seeking 22.9 4.9 8 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/9 TCI Reward dependence 14.4 3.2 8 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/9 TCI Persistence 4.4 1.4 8 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/9 TCI Harm avoidance 14.9 4.3 8 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/10 TCI Novelty seeking 20.3 5.3 56 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/10 TCI Reward dependence 13.7 3.4 56 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/10 TCI Persistence 4.3 1.9 56 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 9/10 TCI Harm avoidance 16.2 6.4 56 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 10/10 TCI Novelty seeking 20.6 6.1 63 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 10/10 TCI Reward dependence 15.0 3.9 63 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 10/10 TCI Persistence 4.7 1.9 63 Healthy Polish medical students 11340364
SLC6A3 40-bp VNTR 10/10 TCI Harm avoidance 16.4 6.4 63 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR short/short TCI Novelty seeking 18.8 5.5 18 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR short/short TCI Reward dependence 14.8 3.5 18 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR short/short TCI Persistence 4.4 1.3 18 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR short/short TCI Harm avoidance 16.1 5.9 18 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/short TCI Novelty seeking 20.9 5.4 67 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/short TCI Reward dependence 14.7 3.6 67 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/short TCI Persistence 4.5 1.9 67 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/short TCI Harm avoidance 15.4 6.4 67 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/long TCI Novelty seeking 20.9 6.2 41 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/long TCI Reward dependence 13.4 3.8 41 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/long TCI Persistence 4.5 1.8 41 Healthy Polish medical students 11340364
SLC6A4 5-HTTLPR long/long TCI Harm avoidance 17.5 6.1 41 Healthy Polish medical students 11340364
SLC6A2 A1287G G/G TCI Novelty seeking 21.3 6.9 9 Healthy Polish medical students 11340364
SLC6A2 A1287G G/G TCI Reward dependence 14.0 3.6 9 Healthy Polish medical students 11340364
SLC6A2 A1287G G/G TCI Persistence 4.2 1.5 9 Healthy Polish medical students 11340364
SLC6A2 A1287G G/G TCI Harm avoidance 15.3 5.4 9 Healthy Polish medical students 11340364
SLC6A2 A1287G A/G TCI Novelty seeking 21.2 5.9 51 Healthy Polish medical students 11340364
SLC6A2 A1287G A/G TCI Reward dependence 14.4 4.1 51 Healthy Polish medical students 11340364
SLC6A2 A1287G A/G TCI Persistence 4.5 1.9 51 Healthy Polish medical students 11340364
SLC6A2 A1287G A/G TCI Harm avoidance 16.5 7.0 51 Healthy Polish medical students 11340364
SLC6A2 A1287G A/A TCI Novelty seeking 20.0 5.2 49 Healthy Polish medical students 11340364
SLC6A2 A1287G A/A TCI Reward dependence 15.0 3.6 49 Healthy Polish medical students 11340364
SLC6A2 A1287G A/A TCI Persistence 4.7 1.9 49 Healthy Polish medical students 11340364
SLC6A2 A1287G A/A TCI Harm avoidance 16.1 5.5 49 Healthy Polish medical students 11340364
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