Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers

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Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers
Authors: Jerzy Samochowiec, Szymon Syrek, Parus Michal, Aneta Ryzewska-Wodecka, Agnieszka Samochowiec, Jan Horodnicki, Marzena Zakrzewska, Jolanta Kucharska-Mazur
Citation: Neuropsychobiology 50 (2): 174-171. 2004
Database(s): PubMed (PMID/15292674)
DOI: 10.1159/000079111.
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Extract:

Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers reports a personality genetics study on the 5-HTTLPR and MAOA-uVNTR genetic polymorphisms and personality traits assessed with both NEO-FFI and Temperament and Character Inventory.

[edit] Subjects

Subject group #1 (help)
Female Polish volunteers
Subjects/♂/♀: 53 / 0 / 53
Age: 71 ±17 (–)
Nationality: Polish
Approval: Ethics Committee of the Pomeranian Medical University in Szezecin
Databases:

Group 1 of 53 female Polish volunteers with 0 males and 53 females were included in the study. The Polish group had a mean age of 71.

The study on the human subjects was approved by the Ethics Committee of the Pomeranian Medical University in Szezecin.
Subject group #2 (help)
Male Polish volunteers
Subjects/♂/♀: 53 / 47 / 0
Age: 71 ±17 (–)
Nationality: Polish
Approval: Ethics Committee of the Pomeranian Medical University in Szezecin
Databases:

Group 2 of 53 male Polish volunteers with 47 males and 0 females were included in the study. The Polish group had a mean age of 71. The study on the human subjects was approved by the Ethics Committee of the Pomeranian Medical University in Szezecin.

[edit] Results

Gene Polymorphism Genotype Inventory Trait Mean Std Subjects Recruitment PMID
SLC6A4 5-HTTLPR long/long NEO-FFI Neuroticism 4.86 1.91 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Extraversion 5.68 1.81 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Openness to experience 5.77 1.45 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Agreeableness 5.18 1.26 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Conscientiousness 5.41 2.09 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short NEO-FFI Neuroticism 5.56 2.55 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short NEO-FFI Extraversion 5.84 1.97 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short NEO-FFI Openness to experience 5.04 1.81 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short NEO-FFI Agreeableness 5.36 1.66 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short NEO-FFI Conscientiousness 6.16 1.37 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Neuroticism 5.36 2.22 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Extraversion 5.64 1.89 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Openness to experience 5.45 1.99 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Agreeableness 5.45 1.99 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long NEO-FFI Conscientiousness 5.86 1.75 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short NEO-FFI Neuroticism 4.55 2.08 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short NEO-FFI Extraversion 5.77 1.98 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short NEO-FFI Openness to experience 5.87 2.19 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short NEO-FFI Agreeableness 5.16 1.55 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short NEO-FFI Conscientiousness 5.87 2.00 31 Healthy Polish females 15292674
MAOA uVNTR 4 NEO-FFI Neuroticism 5.03 2.50 31 Healthy Polish males 15292674
MAOA uVNTR 4 NEO-FFI Extraversion 5.74 1.93 31 Healthy Polish males 15292674
MAOA uVNTR 4 NEO-FFI Openness to experience 5.74 1.67 31 Healthy Polish males 15292674
MAOA uVNTR 4 NEO-FFI Agreeableness 5.32 1.40 31 Healthy Polish males 15292674
MAOA uVNTR 4 NEO-FFI Conscientiousness 6.00 1.75 31 Healthy Polish males 15292674
MAOA uVNTR 3 NEO-FFI Neuroticism 5.63 1.78 16 Healthy Polish males 15292674
MAOA uVNTR 3 NEO-FFI Extraversion 5.81 1.83 16 Healthy Polish males 15292674
MAOA uVNTR 3 NEO-FFI Openness to experience 4.89 1.49 16 Healthy Polish males 15292674
MAOA uVNTR 3 NEO-FFI Agreeableness 5.19 1.64 16 Healthy Polish males 15292674
MAOA uVNTR 3 NEO-FFI Conscientiousness 5.44 1.79 16 Healthy Polish males 15292674
MAOA uVNTR 4 NEO-FFI Neuroticism 4.78 1.96 44 Healthy Polish females 15292674
MAOA uVNTR 4 NEO-FFI Extraversion 6.06 1.54 44 Healthy Polish females 15292674
MAOA uVNTR 4 NEO-FFI Openness to experience 5.88 1.91 44 Healthy Polish females 15292674
MAOA uVNTR 4 NEO-FFI Agreeableness 5.53 1.78 44 Healthy Polish females 15292674
MAOA uVNTR 4 NEO-FFI Conscientiousness 6.00 1.57 44 Healthy Polish females 15292674
MAOA uVNTR 3 NEO-FFI Neuroticism 5.05 2.46 56 Healthy Polish females 15292674
MAOA uVNTR 3 NEO-FFI Extraversion 5.19 2.32 56 Healthy Polish females 15292674
MAOA uVNTR 3 NEO-FFI Openness to experience 5.43 2.18 56 Healthy Polish females 15292674
MAOA uVNTR 3 NEO-FFI Agreeableness 4.90 1.64 56 Healthy Polish females 15292674
MAOA uVNTR 3 NEO-FFI Conscientiousness 5.57 2.31 56 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Novelty seeking 18.00 3.80 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Reward dependence 14.59 3.42 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Persistence 4.23 1.69 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Harm avoidance 14.50 5.31 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Novelty seeking 19.24 5.20 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Reward dependence 13.04 2.88 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Persistence 4.16 1.64 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Harm avoidance 12.76 5.58 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Novelty seeking 18.50 4.38 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Reward dependence 15.23 3.93 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Persistence 4.18 1.99 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Harm avoidance 15.95 6.05 22 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Novelty seeking 17.19 4.76 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Reward dependence 13.97 3.17 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Persistence 4.19 2.07 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Harm avoidance 15.32 4.08 31 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Novelty seeking 18.19 4.55 31 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Reward dependence 13.13 3.64 31 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Persistence 4.03 1.56 31 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Harm avoidance 14.10 5.82 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Novelty seeking 19.56 4.59 16 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Reward dependence 15.00 2.58 16 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Persistence 4.50 1.93 16 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Harm avoidance 12.56 4.73 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Novelty seeking 17.56 4.92 32 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Reward dependence 14.72 3.39 32 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Persistence 4.03 1.93 32 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Harm avoidance 15.84 5.12 32 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Novelty seeking 18.00 4.20 21 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Reward dependence 14.14 2.65 21 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Persistence 4.43 2.18 21 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Harm avoidance 15.12 4.87 21 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Exploratory excitability 5.4 1.7 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Exploratory excitability 5.4 1.9 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Exploratory excitability 4.3 1.8 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Exploratory excitability 5.4 2.3 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Exploratory excitability 6.0 1.7 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Exploratory excitability 5.1 1.8 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Exploratory excitability 5.1 1.8 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Exploratory excitability 4.5 2.2 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Impulsiveness 5.2 1.7 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Impulsiveness 4.4 1.5 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Impulsiveness 5.1 1.6 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Impulsiveness 4.6 1.7 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Impulsiveness 5.2 1.6 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Impulsiveness 4.7 1.7 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Impulsiveness 4.9 1.6 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Impulsiveness 4.8 1.8 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Extravagance 4.5 1.7 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Extravagance 4.1 1.2 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Extravagance 4.0 1.7 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Extravagance 4.1 1.8 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Extravagance 4.4 1.9 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Extravagance 4.2 1.3 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Extravagance 4.1 1.6 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Extravagance 4.0 1.8 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Disorderliness 4.2 1.7 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Disorderliness 4.1 2.0 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Disorderliness 3.9 1.6 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Disorderliness 4.4 1.9 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Disorderliness 4.0 1.8 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Disorderliness 4.2 1.8 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Disorderliness 3.9 1.7 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Disorderliness 4.3 1.7 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Sentimentality 6.1 2.4 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Sentimentality 7.0 2.2 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Sentimentality 7.2 2.1 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Sentimentality 7.4 1.9 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Sentimentality 7.1 1.7 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Sentimentality 6.2 2.5 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Sentimentality 7.0 2.0 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Sentimentality 7.4 2.0 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Attachment 4.4 1.4 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Attachment 4.6 1.4 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Attachment 4.4 1.3 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Attachment 4.8 1.3 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Attachment 5.3 1.3 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Attachment 4.1 1.2 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Attachment 4.5 1.2 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Attachment 4.6 1.4 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Dependence 2.5 1.1 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Dependence 3.0 1.3 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Dependence 2.4 1.2 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Dependence 3.1 1.4 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Dependence 2.6 1.4 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Dependence 2.8 1.2 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Dependence 2.7 1.2 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Dependence 2.7 1.4 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Anticipatory worry 3.8 2.2 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Anticipatory worry 4.0 2.3 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Anticipatory worry 4.3 1.6 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Anticipatory worry 4.0 1.9 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Anticipatory worry 3.5 1.7 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Anticipatory worry 4.1 2.5 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Anticipatory worry 4.0 1.2 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Anticipatory worry 4.4 2.0 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Fear of uncertainty 3.0 2.0 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Fear of uncertainty 3.6 1.9 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Fear of uncertainty 3.9 1.7 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Fear of uncertainty 4.2 1.7 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Fear of uncertainty 2.5 1.7 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Fear of uncertainty 3.7 2.0 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Fear of uncertainty 4.1 1.7 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Fear of uncertainty 4.0 1.7 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Shyness with strangers 2.6 1.6 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Shyness with strangers 3.4 1.9 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Shyness with strangers 3.6 1.8 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Shyness with strangers 3.4 2.1 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Shyness with strangers 3.1 1.7 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Shyness with strangers 3.0 1.9 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Shyness with strangers 3.4 1.9 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Shyness with strangers 3.7 1.9 32 Healthy Polish females 15292674
SLC6A4 5-HTTLPR short TCI Fatigability and asthenia 3.4 1.4 25 Healthy Polish males 15292674
SLC6A4 5-HTTLPR long/long TCI Fatigability and asthenia 3.5 1.7 22 Healthy Polish males 15292674
SLC6A4 5-HTTLPR short TCI Fatigability and asthenia 3.4 1.6 31 Healthy Polish females 15292674
SLC6A4 5-HTTLPR long/long TCI Fatigability and asthenia 4.2 1.6 22 Healthy Polish females 15292674
MAOA uVNTR 3 TCI Fatigability and asthenia 3.5 1.5 16 Healthy Polish males 15292674
MAOA uVNTR 4 TCI Fatigability and asthenia 3.4 1.6 31 Healthy Polish males 15292674
MAOA uVNTR 3 TCI Fatigability and asthenia 3.8 1.9 21 Healthy Polish females 15292674
MAOA uVNTR 4 TCI Fatigability and asthenia 3.8 1.5 32 Healthy Polish females 15292674


[edit] Critique

  1. Typos: "20.6" in Table 3 should probably be 2.06. "SCL 6A4" in the caption should be "SLC6A4".
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